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Study · In vitro (cells) · rat · 2015

6 results

Direct stimulatory effects of oxytocin in female rat gonadotrophs and somatotrophs in vitro: comparison with lactotrophs.

Gonzalez-Iglesias AE, Fletcher PA, Arias-Cristancho JA, Cristancho-Gordo R, Helena CV, Bertram R, Tabak J

Endocrinology19 Nov 2014Cited by 16 (Europe PMC)

PMID25406939 (opens in a new tab)PMCIDPMC4298322 (opens in a new tab)DOI10.1210/en.2014-1543 (opens in a new tab)PepBankPUB-25406939
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In female rat pituitary cells, oxytocin stimulated transients of intracellular Ca2+ concentration in somatotrophs and gonadotrophs.

    In plain wordsIn rat pituitary cells in a dish, oxytocin raised calcium signals in growth-hormone and reproductive-hormone cells.

    Peptide
    Oxytocin
    Outcome
    IncreaseIntracellular Ca2+ transients in somatotrophs and gonadotrophs
    Study

    ratn: not reported in source

    Primary culture of female rat pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT also stimulates transients of intracellular Ca(2+) concentration in somatotrophs and gonadotrophs as well as
  2. 02LabIn vitro (cells)Activity measurement

    In female rat pituitary cells, oxytocin stimulated growth hormone release in a dose-dependent manner.

    In plain wordsIn rat pituitary cells in a dish, oxytocin increased growth hormone release, more at higher doses.

    Peptide
    Oxytocin
    Outcome
    IncreaseGH release
    Study

    ratn: not reported in source

    Primary culture of female rat pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as well as the release of GH and LH in a dose-dependent manner with EC50 values that closely correspond to the ligand affinity of the OT receptor (OTR).
  3. 03LabIn vitro (cells)Activity measurement

    In female rat pituitary cells, oxytocin stimulated luteinizing hormone release in a dose-dependent manner.

    In plain wordsIn rat pituitary cells in a dish, oxytocin increased luteinizing hormone release, more at higher doses.

    Peptide
    Oxytocin
    Outcome
    IncreaseLH release
    Study

    ratn: not reported in source

    Primary culture of female rat pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as well as the release of GH and LH in a dose-dependent manner with EC50 values that closely correspond to the ligand affinity of the OT receptor (OTR).
  4. 04LabIn vitro (cells)Activity measurement

    In female rat pituitary cells, the hormone-releasing effect of oxytocin in gonadotrophs and somatotrophs was 2 orders of magnitude more sensitive than in lactotrophs.

    In plain wordsIn rat pituitary cells in a dish, oxytocin acted at far lower doses on two cell types than on prolactin cells.

    Peptide
    Oxytocin
    Outcome
    IncreaseSensitivity of gonadotrophs and somatotrophs compared with lactotrophs
    Study

    ratn: not reported in source

    Primary culture of female rat pituitary cells
    Comparator
    Lactotrophs
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, the hormone-releasing effect of OT in these two cell types is 2 orders of magnitude more sensitive than that in lactotrophs.
  5. 05LabIn vitro (cells)Mechanism

    In female rat pituitary cells, the effects of oxytocin on hormone release and intracellular Ca2+ were abolished by a specific oxytocin receptor antagonist but not by a selective vasopressin V1a receptor antagonist.

    In plain wordsIn rat pituitary cells in a dish, oxytocin acted through its own receptor and not through the vasopressin receptor.

    Peptide
    Oxytocin
    Outcome
    Not applicableBlockade by oxytocin receptor antagonist
    Study

    ratn: not reported in source

    Primary culture of female rat pituitary cells
    Comparator
    Vasopressin V1a receptor antagonist
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the effects on hormone release and intracellular Ca(2+) of both OT and [Thr(4),Gly(7)]oxytocin were abolished by the specific OT receptor antagonist desGly-NH2-d(CH2)5[D-Tyr(2),Thr(4)]OVT but not by the highly selective vasopressin V1a receptor antagonist
  6. 06LabIn vitro (cells)Activity measurement

    In female rat pituitary cells, 10 nM arginine vasopressin stimulated LH and GH release comparably with a dose of oxytocin that was at least 10 times lower.

    In plain wordsIn rat pituitary cells in a dish, oxytocin released these hormones at a dose at least 10 times lower than vasopressin needed.

    Peptide
    Oxytocin
    Outcome
    Not applicablePotency versus arginine vasopressin for LH and GH release
    Study

    ratn: not reported in source

    Primary culture of female rat pituitary cells
    Comparator
    Arginine vasopressin
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, 10 nM arginine vasopressin stimulated LH and GH release comparably with a dose of OT that was at least 10 times lower.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

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