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Study · Randomized controlled trial · n = 70 · 2015

4 results

The influence of oxytocin on volitional and emotional ambivalence.

Preckel K, Scheele D, Eckstein M, Maier W, Hurlemann R

Social cognitive and affective neuroscience14 Nov 2014Cited by 34 (Europe PMC)

PMID25398434 (opens in a new tab)PMCIDPMC4483569 (opens in a new tab)DOI10.1093/scan/nsu147 (opens in a new tab)PepBankPUB-25398434
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy male volunteers, intranasal oxytocin diminished anterior cingulate cortex responses to ambivalence in both experiments.

    In plain wordsIn healthy men, oxytocin lowered brain activity linked to mixed feelings, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAnterior cingulate cortex response to ambivalence
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In both experiments, intranasal OXT diminished neural responses in the ACC to ambivalence.
    1 context sentence
    Summary · context
    We have conducted two randomized, double-blind, placebo-controlled, functional magnetic resonance imaging experiments involving 70 healthy male volunteers to investigate the effects of the neuropeptide oxytocin (OXT) on neural and behavioral correlates of ambivalence.
  2. 02HumanRandomized controlled trialMechanism

    In healthy male volunteers, oxytocin reduced orbitofrontal cortex activation during moral dilemma vignettes.

    In plain wordsIn healthy men, oxytocin lowered activity in one brain area during moral dilemmas, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseOrbitofrontal cortex activation during moral dilemmas
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Under OXT, moral dilemma vignettes also elicited a reduced activation in the orbitofrontal cortex
    1 context sentence
    Summary · context
    We have conducted two randomized, double-blind, placebo-controlled, functional magnetic resonance imaging experiments involving 70 healthy male volunteers to investigate the effects of the neuropeptide oxytocin (OXT) on neural and behavioral correlates of ambivalence.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy male volunteers, oxytocin lowered the arousal rating of imagined partner infidelity.

    In plain wordsIn healthy men, oxytocin made imagining a partner's infidelity feel less arousing, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseArousal rating of partner infidelity imagery
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    the imagery of partner infidelity was rated as less arousing.
    1 context sentence
    Summary · context
    We have conducted two randomized, double-blind, placebo-controlled, functional magnetic resonance imaging experiments involving 70 healthy male volunteers to investigate the effects of the neuropeptide oxytocin (OXT) on neural and behavioral correlates of ambivalence.
  4. 04HumanRandomized controlled trialMechanism

    In healthy male volunteers, the oxytocin-induced differential activation in the anterior cingulate cortex predicted the size of the arousal reduction.

    In plain wordsIn healthy men, the oxytocin-related change in one brain area matched how much arousal dropped.

    Peptide
    Oxytocin
    Outcome
    Not applicableACC activation predicting arousal reduction
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Interestingly, the OXT-induced differential activation in the ACC predicted the magnitude of arousal reduction.
    1 context sentence
    Summary · context
    We have conducted two randomized, double-blind, placebo-controlled, functional magnetic resonance imaging experiments involving 70 healthy male volunteers to investigate the effects of the neuropeptide oxytocin (OXT) on neural and behavioral correlates of ambivalence.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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