In fourteen patients with treatment-resistant depression who had not responded to escitalopram, 4 weeks of added intranasal oxytocin significantly reduced Hamilton Depression Rating Scale scores in an open trial.
In plain wordsIn fourteen people with depression that had not responded to escitalopram, adding oxytocin spray was linked to lower depression scores, without a control group.
- Peptide
- Oxytocin
- Outcome
- DecreaseHamilton Depression Rating Scale score
- Study
n = 14
- Outcome group
- Anxiety and mood · Mental health and mood
- Studied dose
- Dose not stated · intranasal · 4 weeksAs given in this study (human).
Source sentences
This is the first open trial study suggesting OT in association with escitalopram significantly reduced scores on Hamilton Depression Rating Scale.
1 context sentence(design, population, supporting numbers)
Fourteen patients, who have not responded to 40mg of escitalopram, received intranasal synthetic oxytocin during 4 weeks, in association with antidepressant.