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Study · Animal study (in vivo) · rat · 2014

7 results

Intermittently administered parathyroid hormone [1-34] promotes tendon-bone healing in a rat model.

Bi F, Shi Z, Jiang S, Guo P, Yan S

International journal of molecular sciences29 Sept 2014Cited by 26 (Europe PMC)

PMID25268612 (opens in a new tab)PMCIDPMC4227167 (opens in a new tab)DOI10.3390/ijms151017366 (opens in a new tab)PepBankPUB-25268612
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Summary

The objective of this study was to investigate whether intermittent administration of parathyroid hormone [1-34] (PTH[1-34]) promotes tendon-bone healing after anterior cruciate ligament (ACL) reconstruction in vivo. A rat model of ACL reconstruction with autograft was established at the left hind leg. Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline. The tendon-bone healing process was evaluated by micro-CT, biomechanical test, histological and immunohistochemical analyses. The effects of PTH[1-34] on serum chemistry, bone microarchitecture and expression of the PTH receptor (PTH1R) and osteocalcin were determined. Administration of PTH[1-34] significantly increased serum levels of calcium, alkaline phosphatase (AP), osteocalcin and tartrate-resistant acid phosphatase (TRAP). The expression of PTH1R on both osteocytes and chondrocyte-like cells at the tendon-bone interface was increased in the PTH group. PTH[1-34] also enhanced the thickness and microarchitecture of trabecular bone according to the micro-CT analysis. The results imply that systematically intermittent administration of PTH[1-34] promotes tendon-bone healing at an early stage via up-regulated PTH1R. This method may enable a new strategy for the promotion of tendon-bone healing after ACL reconstruction.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, PTH[1-34] increased serum calcium versus saline.

    In plain wordsIn rats after ACL reconstruction, PTH increased blood calcium compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSerum calcium
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of PTH[1-34] significantly increased serum levels of calcium, alkaline phosphatase (AP), osteocalcin and tartrate-resistant acid phosphatase (TRAP).
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, PTH[1-34] increased serum alkaline phosphatase versus saline.

    In plain wordsIn rats after ACL reconstruction, PTH increased alkaline phosphatase compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSerum alkaline phosphatase
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of PTH[1-34] significantly increased serum levels of calcium, alkaline phosphatase (AP), osteocalcin and tartrate-resistant acid phosphatase (TRAP).
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, PTH[1-34] increased serum osteocalcin versus saline.

    In plain wordsIn rats after ACL reconstruction, PTH increased osteocalcin compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSerum osteocalcin
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of PTH[1-34] significantly increased serum levels of calcium, alkaline phosphatase (AP), osteocalcin and tartrate-resistant acid phosphatase (TRAP).
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, PTH[1-34] increased serum TRAP versus saline.

    In plain wordsIn rats after ACL reconstruction, PTH increased TRAP compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSerum TRAP
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of PTH[1-34] significantly increased serum levels of calcium, alkaline phosphatase (AP), osteocalcin and tartrate-resistant acid phosphatase (TRAP).
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In reconstructed rat knees, PTH increased PTH1R expression on osteocytes and chondrocyte-like cells at the tendon-bone interface.

    In plain wordsIn rats, PTH increased receptor expression at the tendon-bone interface compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseInterface PTH1R expression
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    The expression of PTH1R on both osteocytes and chondrocyte-like cells at the tendon-bone interface was increased in the PTH group.
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In reconstructed rat knees, PTH enhanced trabecular bone thickness versus saline.

    In plain wordsIn rats, PTH increased trabecular bone thickness compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    PTH[1-34] also enhanced the thickness and microarchitecture of trabecular bone according to the micro-CT analysis.
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In reconstructed rat knees, PTH enhanced trabecular bone microarchitecture versus saline.

    In plain wordsIn rats, PTH improved trabecular bone structure compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular microarchitecture
    Study

    ratn = 20

    ACL reconstruction with autograft
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 μg/kg daily · subcutaneous · four weeksAs given in this study (rat).

    Source sentences

    Summary
    PTH[1-34] also enhanced the thickness and microarchitecture of trabecular bone according to the micro-CT analysis.
    2 context sentences
    Summary · context
    A rat model of ACL reconstruction with autograft was established at the left hind leg.
    Summary · context
    Every day, injections of 60 μg PTH[1-34]/kg subcutaneously were given to the PTH group rats (n=10) for four weeks, and the controls (n=10) received saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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