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Study · In vitro (cells) · 2014

6 results

Favorable interleukin-8 induction in human gingival epithelial cells by the antimicrobial peptide LL-37.

Montreekachon P, Nongparn S, Sastraruji T, Khongkhunthian S, Chruewkamlow N, Kasinrerk W, Krisanaprakornkit S

Asian Pacific journal of allergy and immunology1 Sept 2014Cited by 13 (Europe PMC)

PMID25268344 (opens in a new tab)DOI10.12932/ap0404.32.3.2014 (opens in a new tab)PepBankPUB-25268344
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human gingival epithelial cells, non-toxic doses of LL‑37 significantly raised IL-8 levels in the cell-free culture supernatant versus untreated cells.

    In plain wordsIn gum cell cultures, LL‑37 at non-toxic doses raised IL-8, a signal that attracts immune cells, compared with untreated cells.

    Peptide
    LL-37
    Outcome
    IncreaseIL-8 level in culture supernatant
    Study

    humann: not reported in source

    human gingival epithelial cells (HGECs)
    Comparator
    Untreated cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    2-6 μMAs given in this study (human).

    Measurements

    Non-toxic LL-37 dose range
    2 to 6 μM
    HGECs

    Source sentences

    Summary
    Out of eleven Th1/Th2 cytokines tested, treatment of HGECs with non-toxic doses of LL-37 (2-6 μM) significantly raised only IL-8 levels in the cell-free culture supernatants, when compared to control untreated cells (P <0.05).
    1 context sentence
    Summary · context
    Cultured HGECs were treated with different concentrations of LL-37 for different numbers of times.
  2. 02LabIn vitro (cells)Activity measurement

    In human gingival epithelial cells, non-toxic doses of LL‑37 did not significantly raise the levels of the other tested Th1/Th2 cytokines, only IL-8.

    In plain wordsIn gum cell cultures, LL‑37 at non-toxic doses raised only IL-8 and none of the other tested immune signals, compared with untreated cells.

    Peptide
    LL-37
    Outcome
    No significant changeOther Th1/Th2 cytokine levels in culture supernatant
    Study

    humann: not reported in source

    human gingival epithelial cells (HGECs)
    Comparator
    Untreated cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    2-6 μMAs given in this study (human).

    Source sentences

    Summary
    Out of eleven Th1/Th2 cytokines tested, treatment of HGECs with non-toxic doses of LL-37 (2-6 μM) significantly raised only IL-8 levels in the cell-free culture supernatants, when compared to control untreated cells (P <0.05).
    1 context sentence
    Summary · context
    Cultured HGECs were treated with different concentrations of LL-37 for different numbers of times.
  3. 03LabIn vitro (cells)Activity measurement

    In human gingival epithelial cells, LL‑37 treatment significantly induced IL-8 mRNA expression versus untreated cells.

    In plain wordsIn gum cell cultures, LL‑37 clearly switched on the IL-8 gene compared with untreated cells.

    Peptide
    LL-37
    Outcome
    IncreaseIL-8 mRNA expression
    Study

    humann: not reported in source

    human gingival epithelial cells (HGECs)
    Comparator
    Untreated cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consistent with the elevated IL-8 levels, IL-8 mRNA expression was remarkably and significantly induced by LL-37 treatment (P < 0.05), when compared to the modest mRNA induction of other three cytokines, including IL-1β, IL-6, and TNF-α.
    1 context sentence
    Summary · context
    Cultured HGECs were treated with different concentrations of LL-37 for different numbers of times.
  4. 04LabIn vitro (cells)Activity measurement

    In human gingival epithelial cells, LL‑37 induced only modest mRNA expression of IL-1β, IL-6 and TNF-α, compared with the induction of IL-8.

    In plain wordsIn gum cell cultures, LL‑37 switched on the genes for three other immune signals only a little, compared with IL-8.

    Peptide
    LL-37
    Outcome
    IncreaseIL-1β, IL-6 and TNF-α mRNA expression
    Study

    humann: not reported in source

    human gingival epithelial cells (HGECs)
    Comparator
    Untreated cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consistent with the elevated IL-8 levels, IL-8 mRNA expression was remarkably and significantly induced by LL-37 treatment (P < 0.05), when compared to the modest mRNA induction of other three cytokines, including IL-1β, IL-6, and TNF-α.
    1 context sentence
    Summary · context
    Cultured HGECs were treated with different concentrations of LL-37 for different numbers of times.
  5. 05LabIn vitro (cells)Activity measurement

    In human gingival epithelial cells, LL‑37 treatment caused a cumulative induction of IL-8 mRNA within a 24-hour interval.

    In plain wordsIn gum cell cultures, IL-8 gene activity kept building up during 24 hours of LL‑37 treatment.

    Peptide
    LL-37
    Outcome
    IncreaseIL-8 mRNA induction over time
    Study

    humann: not reported in source

    human gingival epithelial cells (HGECs)
    Comparator
    Untreated cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The time-course study demonstrated a cumulative IL-8 mRNA induction by LL-37 treatment within a 24-hour interval.
    1 context sentence
    Summary · context
    Cultured HGECs were treated with different concentrations of LL-37 for different numbers of times.
  6. 06LabIn vitro (cells)Safety outcome

    In human gingival epithelial cells, LL‑37 at 2-6 μM was non-toxic in the MTT cytotoxicity assay.

    In plain wordsIn gum cell cultures, LL‑37 at 2-6 μM did not harm the cells.

    Peptide
    LL-37
    Outcome
    No significant changeCytotoxicity of LL-37 in HGECs
    Study

    humann: not reported in source

    human gingival epithelial cells (HGECs)
    Outcome group
    Adverse events · Whole body
    Studied dose
    2-6 μMAs given in this study (human).

    Measurements

    Non-toxic LL-37 dose range
    2 to 6 μM
    HGECs

    Source sentences

    Summary
    Out of eleven Th1/Th2 cytokines tested, treatment of HGECs with non-toxic doses of LL-37 (2-6 μM) significantly raised only IL-8 levels in the cell-free culture supernatants, when compared to control untreated cells (P <0.05).
    2 context sentences
    Summary · context
    The cytotoxicity of LL-37 was determined by an MTT assay.
    Summary · context
    Cultured HGECs were treated with different concentrations of LL-37 for different numbers of times.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:57 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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