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Study · Animal study (in vivo) · mouse · 2015

9 results

Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair.

Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society29 Sept 2014Cited by 18 (Europe PMC)

PMID25266795 (opens in a new tab)PMCIDPMC4241167 (opens in a new tab)DOI10.1002/jor.22735 (opens in a new tab)PepBankPUB-25266795
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, PTH 1‑34 reduced joint range of motion versus vehicle control.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 reduced joint movement versus vehicle control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseJoint range of motion
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Range of motion reduction
    1.5 to 2 fold
    PTH 1-34 versus control

    Source sentences

    Summary
    The metatarsophalangeal joint range of motion was reduced 1.5-2-fold in PTH 1-34 mice compared to control mice.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, the gliding coefficient was higher with PTH 1‑34 than vehicle control.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 increased a measure of adhesions versus vehicle control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseGliding coefficient
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Gliding coefficient increase
    2 to 3.5 fold
    PTH 1-34 versus control

    Source sentences

    Summary
    The gliding coefficient, a measure of adhesion formation, was 2-3.5-fold higher in PTH 1-34 mice.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, tensile strength was twofold higher with PTH 1‑34 than control at 14 days.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 increased tensile strength versus control at 14 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTensile strength at 14 days
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    At 14 days post-repair, the tensile strength was twofold higher in PTH 1-34 specimens, but at 28 days there were no differences.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, tensile strength did not differ between PTH 1‑34 and control at 28 days.

    In plain wordsIn mice with repaired tendons, tensile strength did not differ between PTH 1‑34 and control at 28 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeTensile strength at 28 days
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    At 14 days post-repair, the tensile strength was twofold higher in PTH 1-34 specimens, but at 28 days there were no differences.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, PTH 1‑34 increased fibrous tissue deposition versus control.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 increased fibrous tissue deposits versus control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFibrous tissue deposition
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    PTH 1-34 mice had increased fibrous tissue deposition that correlated with elevated expression of collagens and fibronectin as seen on quantitative PCR.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with repaired flexor tendons, PTH 1‑34 increased collagen expression, which correlated with greater fibrous tissue deposition.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 increased collagen expression versus control, alongside greater fibrous tissue deposits.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCollagen expression
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    PTH 1-34 mice had increased fibrous tissue deposition that correlated with elevated expression of collagens and fibronectin as seen on quantitative PCR.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with repaired flexor tendons, PTH 1‑34 increased fibronectin expression, which correlated with greater fibrous tissue deposition.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 increased fibronectin expression versus control, alongside greater fibrous tissue deposits.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFibronectin expression
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    PTH 1-34 mice had increased fibrous tissue deposition that correlated with elevated expression of collagens and fibronectin as seen on quantitative PCR.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, PTH 1‑34 accelerated reparative tissue deposition versus control.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 accelerated repair tissue deposits versus control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseReparative tissue deposition
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    PTH 1-34 accelerated the deposition of reparative tissue but increased adhesion formation.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with repaired flexor tendons, PTH 1‑34 increased adhesion formation versus control.

    In plain wordsIn mice with repaired tendons, PTH 1‑34 increased adhesions versus control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseAdhesion formation
    Study

    mousen: not reported in source

    C57Bl/6J flexor digitorum longus tendon repair
    Comparator
    Vehicle control (PBS)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    PTH 1-34 accelerated the deposition of reparative tissue but increased adhesion formation.
    2 context sentences
    Summary · context
    C57Bl/6J mice were treated with either intraperitoneal PTH 1-34 or vehicle-control (PBS).
    Summary · context
    Tendons were harvested at 3-28 days for histology, gene expression, and biomechanical testing.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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