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Study · Animal study (in vivo) · rat · 2014

1 result

Intraportal infusion of ghrelin could inhibit glucose-stimulated GLP-1 secretion by enteric neural net in Wistar rat.

Zhang X, Li W, Li P, Chang M, Huang X, Li Q, Cui C

BioMed research international26 Aug 2014Cited by 3 (Europe PMC)

PMID25247193 (opens in a new tab)PMCIDPMC4160649 (opens in a new tab)DOI10.1155/2014/923564 (opens in a new tab)PepBankPUB-25247193
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Summary

As a regulator of food intake and energy metabolism, the role of ghrelin in glucose metabolism is still not fully understood. In this study, we determined the in vivo effect of ghrelin on incretin effect. We demonstrated that ghrelin inhibited the glucose-stimulated release of glucagon-like peptide-1 (GLP-1) when infused into the portal vein of Wistar rat. Hepatic vagotomy diminished the inhibitory effect of ghrelin on glucose-stimulated GLP-1 secretion. In addition, phentolamine, a nonselective α receptor antagonist, could recover the decrease of GLP-1 release induced by ghrelin infusion. Pralmorelin (an artificial growth hormone release peptide) infusion into the portal vein could also inhibit the glucose-stimulated release of GLP-1. And growth hormone secretagogue receptor antagonist, [D-lys3]-GHRP-6, infusion showed comparable increases of glucose stimulated GLP-1 release compared to ghrelin infusion into the portal vein. The data showed that intraportal infusion of ghrelin exerted an inhibitory effect on GLP-1 secretion through growth hormone secretagogue receptor 1α (GHS1α receptor), which indicated that the downregulation of ghrelin secretion after food intake was necessary for incretin effect. Furthermore, our results suggested that the enteric neural net involved hepatic vagal nerve and sympathetic nerve mediated inhibition effect of ghrelin on incretin effect.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, pralmorelin infused into the portal vein inhibited glucose-stimulated release of GLP-1.

    In plain wordsIn rats, pralmorelin infused into the portal vein lowered the release of the gut hormone GLP-1 after glucose.

    Peptide
    GHRP-2
    Outcome
    DecreaseGlucose-stimulated GLP-1 release
    Study

    ratn: not reported in source

    Wistar rat, portal vein infusion
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated · intraportal infusionAs given in this study (rat).

    Source sentences

    Summary
    Pralmorelin (an artificial growth hormone release peptide) infusion into the portal vein could also inhibit the glucose-stimulated release of GLP-1.
    1 context sentence
    Title · context
    Intraportal infusion of ghrelin could inhibit glucose-stimulated GLP-1 secretion by enteric neural net in Wistar rat.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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