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Study · Measured the body's own peptide · 2014

1 result

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses.

Sørensen OE, Clemmensen SN, Dahl SL, Østergaard O, Heegaard NH, Glenthøj A, Nielsen FC, Borregaard N

The Journal of clinical investigation17 Sept 2014Cited by 144 (Europe PMC)

PMID25244098 (opens in a new tab)PMCIDPMC4191054 (opens in a new tab)DOI10.1172/jci76009 (opens in a new tab)PepBankPUB-25244098
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelCase report or seriesMechanism

    In a patient with Papillon-Lefevre syndrome, neutrophils could not process endogenous hCAP-18 into LL‑37 in response to ionomycin.

    In plain wordsIn one patient with this syndrome, white blood cells could not make the body's own LL‑37 from its precursor.

    Peptide
    LL-37
    Outcome
    DecreaseProcessing of hCAP-18 into LL-37 in patient neutrophils
    Study

    n = 1

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    were unable to process endogenous cathelicidin hCAP-18 into the antibacterial peptide LL-37 in response to ionomycin.
    1 context sentence
    Summary · context
    Here, we characterized a 24-year-old woman who had suffered from severe juvenile periodontal disease, but was otherwise healthy, and identified a homozygous missense mutation in CTSC indicative of PLS.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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