Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide.

Miyakoshi N, Aizawa T, Sasaki S, Ando S, Maekawa S, Aonuma H, Tsuchie H, Sasaki H, Kasukawa Y, Shimada Y

Journal of bone and mineral metabolism17 Sept 2014Cited by 77 (Europe PMC)

PMID25227287DOI10.1007/s00774-014-0617-3PepBankPUB-25227287

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanObservational studyEfficacy outcome
In surgically treated atypical femoral fractures, teriparatide use was linked to shorter healing time than no teriparatide.
In plain wordsIn surgically treated atypical thighbone fractures, teriparatide use was linked to faster healing than no teriparatide.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseHealing time in surgically treated AFFs
Study
n: not reported in source
Comparator
No teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Measurements
Healing time
5.4 months
teriparatide
Healing time
8.6 months
no teriparatide
Source sentences
Summary
In subanalyses for all AFFs treated surgically, mean (± standard deviation) time to fracture healing was significantly better in the TPTD group (5.4 ± 1.5 months) than in the non-TPTD group (8.6 ± 4.7 months; P = 0.012)
2 context sentences(design, population, supporting numbers)
Summary · context
Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups.
Summary · context
Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed.
Report a problemFND-2522728701
02HumanObservational studyEfficacy outcome
In surgically treated atypical femoral fractures, teriparatide use was linked to less delayed healing or non-union than no teriparatide.
In plain wordsIn surgically treated atypical thighbone fractures, teriparatide use was linked to fewer healing delays or failures than no teriparatide.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseDelayed healing or non-union in surgically treated AFFs
Study
n: not reported in source
Comparator
No teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
the frequency of delayed healing or non-union was significantly lower in the TPTD group than in the non-TPTD group (P = 0.014).
2 context sentences(design, population, supporting numbers)
Summary · context
Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups.
Summary · context
Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed.
Report a problemFND-2522728702
03HumanObservational studyEfficacy outcome
In surgically treated complete atypical femoral fractures, teriparatide use was linked to shorter healing time than no teriparatide.
In plain wordsIn surgically treated complete atypical thighbone fractures, teriparatide use was linked to faster healing than no teriparatide.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseHealing time in surgically treated complete AFFs
Study
n: not reported in source
Comparator
No teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups.
3 context sentences(design, population, supporting numbers)
Summary · context
In subanalyses for all AFFs treated surgically, mean (± standard deviation) time to fracture healing was significantly better in the TPTD group (5.4 ± 1.5 months) than in the non-TPTD group (8.6 ± 4.7 months; P = 0.012)
Summary · context
Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups.
Summary · context
Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed.
Report a problemFND-2522728703
04HumanObservational studyEfficacy outcome
In surgically treated complete atypical femoral fractures, teriparatide use was linked to less delayed healing or non-union than no teriparatide.
In plain wordsIn surgically treated complete atypical thighbone fractures, teriparatide use was linked to fewer healing delays or failures than no teriparatide.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseDelayed healing or non-union in surgically treated complete AFFs
Study
n: not reported in source
Comparator
No teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups.
3 context sentences(design, population, supporting numbers)
Summary · context
the frequency of delayed healing or non-union was significantly lower in the TPTD group than in the non-TPTD group (P = 0.014).
Summary · context
Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups.
Summary · context
Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed.
Report a problemFND-2522728704
05HumanObservational studyEfficacy outcome
In conservatively treated incomplete atypical femoral fractures, healing time did not differ significantly between teriparatide and non-teriparatide groups.
In plain wordsIn incomplete atypical thighbone fractures treated without surgery, healing time did not differ significantly with teriparatide versus no teriparatide.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeHealing time in conservatively treated incomplete AFFs
Study
n: not reported in source
Comparator
No teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Time to fracture-healing and frequency of delayed healing or non-union were compared between groups.
Summary · context
Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups.
Summary · context
Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed.
Report a problemFND-2522728705
06HumanObservational studyEfficacy outcome
In conservatively treated incomplete atypical femoral fractures, delayed healing or non-union did not differ significantly between teriparatide and non-teriparatide groups.
In plain wordsIn incomplete atypical thighbone fractures treated without surgery, healing delays or failures did not differ significantly with teriparatide versus no teriparatide.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeDelayed healing or non-union in conservatively treated incomplete AFFs
Study
n: not reported in source
Comparator
No teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Time to fracture-healing and frequency of delayed healing or non-union were compared between groups.
Summary · context
Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups.
Summary · context
Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed.
Report a problemFND-2522728706

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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