In adults with postdural puncture headache, cosyntropin was 56% effective (95% CI 33-79%) versus 80% for caffeine (95% CI 60-100%).
In plain wordsIn adults with postdural puncture headache, cosyntropin was 56% effective versus 80% for caffeine.
- Peptide
- Cosyntropin
- Outcome
- Direction not reportedTreatment effectiveness without rescue therapy
- Study
n: not reported in source
- Comparator
- Caffeine
- Outcome group
- Pain · Nervous system and cognition
- Studied dose
- Dose not stated · intravenousAs given in this study (human).
Measurements
- Effectiveness (no rescue therapy)
- 56%
- cosyntropin
- 95% CI
- 33 to 79%
- cosyntropin effectiveness
- Effectiveness (no rescue therapy)
- 80%
- caffeine
- 95% CI
- 60 to 100%
- caffeine effectiveness
Source sentences
Caffeine was 80% (95% CI 60-100%) effective and cosyntropin was 56% (95% CI 33-79%) effective in treating post-dural puncture headaches.
3 context sentences(design, population, supporting numbers)
Rescue therapy was documented on the study data forms. Its effectiveness was determined by the need for this therapy.
We performed an interim analysis of a prospective, double blinded, trial of adult patients presenting to the emergency department with a post-dural puncture headache. Patients were randomized to receive either intravenous caffeine or intravenous cosyntropin.
Thirty-seven patients were included and four patients were excluded from the analysis because of protocol violations or incomplete data. Analysis was based on intention-to-treat.