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Study · Animal study (in vivo) · mouse · 2014

10 results

Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice.

Lennox R, Flatt PR, Gault VA

Peptides3 Sept 2014Cited by 38 (Europe PMC)

PMID25195184 (opens in a new tab)DOI10.1016/j.peptides.2014.08.014 (opens in a new tab)PepBankPUB-25195184
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat-fed mice, lixisenatide improved glycemic status, insulin secretion and insulin sensitivity.

    In plain wordsIn mice fed a high-fat diet, lixisenatide improved glucose control and insulin function.

    Peptide
    Lixisenatide
    Outcome
    MixedGlycemic status, insulin secretion and sensitivity
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Lixisenatide (50 nmol/kg bw, twice-daily) resulted in marked improvements in glycemic status, insulin secretion and insulin sensitivity.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide decreased pancreatic islet area.

    In plain wordsIn mice fed a high-fat diet, lixisenatide reduced pancreatic islet area.

    Peptide
    Lixisenatide
    Outcome
    DecreaseIslet area
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Examination of pancreatic tissue revealed decreased islet area, increased islet number, and increased insulin content, with no evidence of pancreatic inflammation.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide increased pancreatic islet number.

    In plain wordsIn mice fed a high-fat diet, lixisenatide increased pancreatic islet number.

    Peptide
    Lixisenatide
    Outcome
    IncreaseIslet number
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Examination of pancreatic tissue revealed decreased islet area, increased islet number, and increased insulin content, with no evidence of pancreatic inflammation.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide increased pancreatic insulin content.

    In plain wordsIn mice fed a high-fat diet, lixisenatide increased insulin content in the pancreas.

    Peptide
    Lixisenatide
    Outcome
    IncreasePancreatic insulin content
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Examination of pancreatic tissue revealed decreased islet area, increased islet number, and increased insulin content, with no evidence of pancreatic inflammation.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In high-fat-fed mice, no pancreatic inflammation was evident after lixisenatide treatment.

    In plain wordsIn mice fed a high-fat diet, no pancreatic inflammation was evident after lixisenatide treatment.

    Peptide
    Lixisenatide
    Outcome
    Not applicablePancreatic inflammation
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Inflammation markers · Endocrine and hormones
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Examination of pancreatic tissue revealed decreased islet area, increased islet number, and increased insulin content, with no evidence of pancreatic inflammation.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat-fed mice, lixisenatide improved recognition memory in a novel object recognition task.

    In plain wordsIn mice fed a high-fat diet, lixisenatide improved recognition memory.

    Peptide
    Lixisenatide
    Outcome
    IncreaseRecognition memory
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Lixisenatide improved recognition memory during a novel object recognition task and this was associated with up-regulation of hippocampal expression of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and mammalian target of rapamycin (mTOR) genes involved in modulating synaptic plasticity and l…
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide increased hippocampal NTRK2 gene expression.

    In plain wordsIn mice fed a high-fat diet, lixisenatide increased hippocampal NTRK2 gene activity.

    Peptide
    Lixisenatide
    Outcome
    IncreaseHippocampal NTRK2 expression
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Lixisenatide improved recognition memory during a novel object recognition task and this was associated with up-regulation of hippocampal expression of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and mammalian target of rapamycin (mTOR) genes involved in modulating synaptic plasticity and l…
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide increased hippocampal mTOR gene expression.

    In plain wordsIn mice fed a high-fat diet, lixisenatide increased hippocampal mTOR gene activity.

    Peptide
    Lixisenatide
    Outcome
    IncreaseHippocampal mTOR expression
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Lixisenatide improved recognition memory during a novel object recognition task and this was associated with up-regulation of hippocampal expression of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and mammalian target of rapamycin (mTOR) genes involved in modulating synaptic plasticity and l…
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide enhanced progenitor cell proliferation in the hippocampal dentate gyrus.

    In plain wordsIn mice fed a high-fat diet, lixisenatide increased precursor cell growth in the hippocampus.

    Peptide
    Lixisenatide
    Outcome
    IncreaseProgenitor cell proliferation
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Lixisenatide also enhanced progenitor cell proliferation and increased the number of immature neurons in the hippocampal dentate gyrus.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In high-fat-fed mice, lixisenatide increased immature neuron numbers in the hippocampal dentate gyrus.

    In plain wordsIn mice fed a high-fat diet, lixisenatide increased immature neuron numbers in the hippocampus.

    Peptide
    Lixisenatide
    Outcome
    IncreaseImmature neuron number
    Study

    micen: not reported in source

    High-fat-fed mice with obesity, insulin resistance and impaired cognition
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 nmol/kg bw, twice-daily · 40 daysAs given in this study (mice).

    Source sentences

    Summary
    Lixisenatide also enhanced progenitor cell proliferation and increased the number of immature neurons in the hippocampal dentate gyrus.
    1 context sentence
    Summary · context
    This study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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