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Study · Randomized controlled trial · n = 40 · 2014

1 result

Oxytocin does not improve performance of patients with schizophrenia and healthy volunteers in a facial emotion matching task.

Horta de Macedo LR, Zuardi AW, Machado-de-Sousa JP, Chagas MH, Hallak JE

Psychiatry research9 Aug 2014Cited by 27 (Europe PMC)

PMID25190346 (opens in a new tab)DOI10.1016/j.psychres.2014.07.082 (opens in a new tab)PepBankPUB-25190346
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with schizophrenia and healthy volunteers, intranasal oxytocin failed to improve facial affect processing versus placebo.

    In plain wordsIn people with schizophrenia and healthy volunteers, oxytocin nasal spray did not improve facial emotion matching compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeFacial affect processing in a facial emotion matching task
    Study

    n = 40

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    48 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin failed to improve facial affect processing, in contrast with previous results.
    1 context sentence
    Summary · context
    Twenty patients and 20 healthy volunteers received 48 IU intranasal oxytocin and placebo in a double-blind, randomized, placebo-controlled, within subjects design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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