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Study · Not a test of the peptide alone · 2014

1 result

Synthesis and biological evaluation of 3-methyl-5-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives for the treatment of diet-induced obesity.

Sang Y, Pei H, Ma L, Huang L, Xie C, Chen J, Liang X, Ran Y, Wang G, Yang Z, Cao D, He L and 5 more

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Wu Y, He L, Zhu J, Lan J, Chen L

Chemical & pharmaceutical bulletin1 Jan 2014

PMID25177017 (opens in a new tab)DOI10.1248/cpb.c14-00258 (opens in a new tab)PepBankPUB-25177017
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Activity measurement

    In 3T3-L1 adipocytes, acadesine showed triglyceride-lowering potency comparable to compound 1i.

    In plain wordsIn cells, acadesine and compound 1i showed comparable ability to lower triglycerides.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeTriglyceride-lowering potency
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Comparator
    compound 1i
    Outcome group
    Lipids · Metabolic and weight

    Source sentences

    Summary
    Among them, compound 1i was found to exhibit potent triglyceride-lowering potency in 3T3-L1 adipocytes which was comparable to that of the adenosine monophosphate-activated protein kinase (AMPK) agonist Acadesine (AIACR).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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