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Study · In vitro (cells) · bovine · 2015

6 results

Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes.

Magdaleno-Méndez A, Domínguez B, Rodríguez-Andrade A, Barrientos-Morales M, Cervantes-Acosta P, Hernández-Beltrán A, González-Ramírez R, Felix R

Endocrine24 Aug 2014Cited by 4 (Europe PMC)

PMID25151402 (opens in a new tab)DOI10.1007/s12020-014-0392-x (opens in a new tab)PepBankPUB-25151402
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In bovine somatotropes, GHRP‑6 increased GH release.

    In plain wordsIn cells from cattle, GHRP‑6 increased growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    Cultured pituitary somatotropes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · chronic treatmentAs given in this study (bovine).

    Source sentences

    Summary
    Here, we reveal that chronic treatment with ghrelin and its synthetic analog GHRP-6 also increases GH release from bovine pituitary somatotropes in culture, and that this action is associated with a significant increase in Na+ macroscopic current.
  2. 02LabIn vitro (cells)Mechanism

    In bovine somatotropes, GHRP‑6 treatment was associated with significantly increased macroscopic sodium current.

    In plain wordsIn cells from cattle, GHRP‑6 treatment was linked to increased sodium current.

    Peptide
    GHRP-6
    Outcome
    IncreaseMacroscopic sodium current
    Study

    bovinen: not reported in source

    Cultured pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · chronic treatmentAs given in this study (bovine).

    Source sentences

    Summary
    Here, we reveal that chronic treatment with ghrelin and its synthetic analog GHRP-6 also increases GH release from bovine pituitary somatotropes in culture, and that this action is associated with a significant increase in Na+ macroscopic current.
  3. 03LabIn vitro (cells)Mechanism

    In bovine somatotropes, GHRP‑6 increased GH transcript levels.

    In plain wordsIn cells from cattle, GHRP‑6 increased growth hormone gene activity.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH transcripts
    Study

    bovinen: not reported in source

    Cultured pituitary somatotropes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · chronic treatmentAs given in this study (bovine).

    Source sentences

    Summary
    Furthermore, semi-quantitative and real-time RT-PCR analysis revealed an upregulation in the transcript levels of GH, as well as of NaV1.1 and NaV1.2, two isoforms of TTX-sensitive Na+ channels expressed in somatotropes, after treatment with ghrelin or GHRP-6.
    1 context sentence
    Summary · context
    Here, we reveal that chronic treatment with ghrelin and its synthetic analog GHRP-6 also increases GH release from bovine pituitary somatotropes in culture, and that this action is associated with a significant increase in Na+ macroscopic current.
  4. 04LabIn vitro (cells)Mechanism

    In bovine somatotropes, GHRP‑6 increased NaV1.1 transcript levels.

    In plain wordsIn cells from cattle, GHRP‑6 increased NaV1.1 gene activity.

    Peptide
    GHRP-6
    Outcome
    IncreaseNaV1.1 transcripts
    Study

    bovinen: not reported in source

    Cultured pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · chronic treatmentAs given in this study (bovine).

    Source sentences

    Summary
    Furthermore, semi-quantitative and real-time RT-PCR analysis revealed an upregulation in the transcript levels of GH, as well as of NaV1.1 and NaV1.2, two isoforms of TTX-sensitive Na+ channels expressed in somatotropes, after treatment with ghrelin or GHRP-6.
    1 context sentence
    Summary · context
    Here, we reveal that chronic treatment with ghrelin and its synthetic analog GHRP-6 also increases GH release from bovine pituitary somatotropes in culture, and that this action is associated with a significant increase in Na+ macroscopic current.
  5. 05LabIn vitro (cells)Mechanism

    In bovine somatotropes, GHRP‑6 increased NaV1.2 transcript levels.

    In plain wordsIn cells from cattle, GHRP‑6 increased NaV1.2 gene activity.

    Peptide
    GHRP-6
    Outcome
    IncreaseNaV1.2 transcripts
    Study

    bovinen: not reported in source

    Cultured pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · chronic treatmentAs given in this study (bovine).

    Source sentences

    Summary
    Furthermore, semi-quantitative and real-time RT-PCR analysis revealed an upregulation in the transcript levels of GH, as well as of NaV1.1 and NaV1.2, two isoforms of TTX-sensitive Na+ channels expressed in somatotropes, after treatment with ghrelin or GHRP-6.
    1 context sentence
    Summary · context
    Here, we reveal that chronic treatment with ghrelin and its synthetic analog GHRP-6 also increases GH release from bovine pituitary somatotropes in culture, and that this action is associated with a significant increase in Na+ macroscopic current.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 06LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In bovine somatotropes, tetrodotoxin abolished the GHRP‑6-induced increase in GH release.

    In plain wordsIn cells from cattle, tetrodotoxin blocked the GHRP‑6-induced increase in growth hormone release.

    Peptide
    GHRP-6
    Outcome
    DecreaseTTX blockade of GH release
    Study

    bovinen: not reported in source

    Cultured pituitary somatotropes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Consistent with this, Na+ current blockade with tetrodotoxin (TTX) abolished the ghrelin- and GHRP-6-induced increase in GH release.
    1 context sentence
    Summary · context
    Here, we reveal that chronic treatment with ghrelin and its synthetic analog GHRP-6 also increases GH release from bovine pituitary somatotropes in culture, and that this action is associated with a significant increase in Na+ macroscopic current.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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