Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS).

Choi YL, Park EJ, Kim E, Na DH, Shin YH

Biomolecules & therapeutics1 Jul 2014Cited by 35 (Europe PMC)

PMID25143811PMCIDPMC4131521DOI10.4062/biomolther.2014.053PepBankPUB-25143811

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

01LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther
In hairless mouse skin preparations, pal-KTTKS degraded rapidly but was more stable than KTTKS.
In plain wordsIn lab tests on mouse skin, pal-KTTKS broke down rapidly but remained more stable than KTTKS.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseDermal stability
Study
mousen: not reported in source
Hairless mouse skin
Comparator
KTTKS
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
Both KTTKS and pal-KTTKS were rapidly degraded, but pal-KTTKS was more stable than KTTKS.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin.
Summary · context
Stability studies were performed using skin extracts and homogenates.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2514381101
02LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther
In hairless mouse skin preparations, protease inhibitors significantly increased pal-KTTKS stability.
In plain wordsIn lab tests on mouse skin, protease inhibitors increased pal-KTTKS stability compared with tests without inhibitors.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseStability with protease inhibitors
Study
mousen: not reported in source
Hairless mouse skin
Comparator
Without protease inhibitors
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
When protease inhibitors were added, the stability of both compounds (KTTKS and pal-KTTKS) improved significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin.
Summary · context
Stability studies were performed using skin extracts and homogenates.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2514381102
03LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther
In full-thickness hairless mouse skin, pal-KTTKS was not detected in the receptor solution.
In plain wordsIn lab tests, pal-KTTKS did not pass through full-thickness mouse skin at detectable levels.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Direction not reportedFull-thickness skin permeation
Study
mousen: not reported in source
Hairless mouse skin
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
In the skin permeation study, neither KTTKS nor pal-KTTKS was detected in the receptor solution, which indicates that neither compound could permeate through the full-thickness hairless mouse skin in the experimental conditions of this study.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin.
Summary · context
Stability studies were performed using skin extracts and homogenates.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2514381103
04LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther
In hairless mouse skin, pal-KTTKS was detected in the stratum corneum.
In plain wordsIn lab tests, pal-KTTKS reached the outer layer of mouse skin.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Not applicableStratum corneum deposition
Study
mousen: not reported in source
Hairless mouse skin
Outcome group
Pharmacokinetics · Skin and wound
Measurements
pal-KTTKS deposition
4.2 μg/cm(2)
stratum corneum
Source sentences
Summary
While KTTKS was not detected in any of the skin layers (the stratum corneum, epidermis, and dermis), pal-KTTKS was observed in all skin layers: 4.2 ± 0.7 μg/cm(2) in the stratum corneum, 2.8 ± 0.5 μg/cm(2) in the epidermis, and 0.3 ± 0.1 μg/cm(2) in the dermis.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin.
Summary · context
Stability studies were performed using skin extracts and homogenates.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2514381104
05LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther
In hairless mouse skin, pal-KTTKS was detected in the epidermis.
In plain wordsIn lab tests, pal-KTTKS reached the epidermis of mouse skin.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Not applicableEpidermal deposition
Study
mousen: not reported in source
Hairless mouse skin
Outcome group
Pharmacokinetics · Skin and wound
Measurements
pal-KTTKS deposition
2.8 μg/cm(2)
epidermis
Source sentences
Summary
While KTTKS was not detected in any of the skin layers (the stratum corneum, epidermis, and dermis), pal-KTTKS was observed in all skin layers: 4.2 ± 0.7 μg/cm(2) in the stratum corneum, 2.8 ± 0.5 μg/cm(2) in the epidermis, and 0.3 ± 0.1 μg/cm(2) in the dermis.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin.
Summary · context
Stability studies were performed using skin extracts and homogenates.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2514381105
06LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther
In hairless mouse skin, pal-KTTKS was detected in the dermis.
In plain wordsIn lab tests, pal-KTTKS reached the dermis of mouse skin.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Not applicableDermal deposition
Study
mousen: not reported in source
Hairless mouse skin
Outcome group
Pharmacokinetics · Skin and wound
Measurements
pal-KTTKS deposition
0.3 μg/cm(2)
dermis
Source sentences
Summary
While KTTKS was not detected in any of the skin layers (the stratum corneum, epidermis, and dermis), pal-KTTKS was observed in all skin layers: 4.2 ± 0.7 μg/cm(2) in the stratum corneum, 2.8 ± 0.5 μg/cm(2) in the epidermis, and 0.3 ± 0.1 μg/cm(2) in the dermis.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin.
Summary · context
Stability studies were performed using skin extracts and homogenates.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2514381106

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Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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