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Study · Animal study (in vivo) · rat · 2014

2 results

Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes.

Meek TH, Matsen ME, Damian V, Cubelo A, Chua SC Jr, Morton GJ

Endocrinology19 Aug 2014Cited by 21 (Europe PMC)

PMID25137027 (opens in a new tab)PMCIDPMC4197991 (opens in a new tab)DOI10.1210/en.2014-1169 (opens in a new tab)PepBankPUB-25137027
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin-induced diabetes, intracerebroventricular melanotan II did not mimic the glucose-lowering effect of leptin.

    In plain wordsIn rats with diabetes, melanotan II given into the brain did not lower blood glucose the way leptin did.

    Peptide
    Melanotan II
    Outcome
    No significant changeBlood glucose in uncontrolled diabetes
    Study

    ratn: not reported in source

    Rats with streptozotocin-induced diabetes
    Comparator
    Vehicle
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Increased central nervous system melanocortin signaling alone fails to mimic leptin's ability to correct any of the metabolic or neuroendocrine disturbances associated with uDM.
    2 context sentences
    Summary · context
    Moreover, the inability of increased melanocortin signaling to lower diabetic hyperglycemia
    Summary · context
    To accomplish this, bilateral cannulae were implanted in the lateral ventricle of rats with streptozotocin-induced diabetes, and leptin was coinfused with varying doses of the melanocortin 3/4 receptor (MC3/4R) antagonist, SHU9119. An additional cohort of streptozotocin-induced diabetes rats receive…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin-induced diabetes, intracerebroventricular melanotan II did not correct the neuroendocrine and metabolic disturbances that leptin corrects, including hyperglucagonemia and ketosis.

    In plain wordsIn rats with diabetes, melanotan II given into the brain did not correct the hormone and metabolic problems that leptin corrects.

    Peptide
    Melanotan II
    Outcome
    No significant changeHyperglucagonemia and ketosis in uncontrolled diabetes
    Study

    ratn: not reported in source

    Rats with streptozotocin-induced diabetes
    Comparator
    Vehicle
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Increased central nervous system melanocortin signaling alone fails to mimic leptin's ability to correct any of the metabolic or neuroendocrine disturbances associated with uDM.
    1 context sentence
    Summary · context
    To accomplish this, bilateral cannulae were implanted in the lateral ventricle of rats with streptozotocin-induced diabetes, and leptin was coinfused with varying doses of the melanocortin 3/4 receptor (MC3/4R) antagonist, SHU9119. An additional cohort of streptozotocin-induced diabetes rats receive…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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