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Study · In vitro (cells) · 2014

2 results

Pretreatment with mechano-growth factor E peptide protects bone marrow mesenchymal cells against damage by fluid shear stress.

Lv Y, Hao X, Sha Y, Yang L

Biotechnology letters17 Aug 2014Cited by 8 (Europe PMC)

PMID25129046 (opens in a new tab)DOI10.1007/s10529-014-1625-z (opens in a new tab)PepBankPUB-25129046
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In bone marrow MSCs, MGF E peptide pretreatment recovered the cellular metabolic activity that 72 dyne cm(-2) fluid shear stress had reduced.

    In plain wordsIn stem cells in a lab dish, MGF E peptide pretreatment restored cell activity that strong fluid stress had lowered.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMSC metabolic activity at 72 dyne cm(-2) FSS
    Study

    n: not reported in source

    bone marrow mesenchymal stem cells (MSCs) exposed to fluid shear stress
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 24 h pretreatmentAs given in this study.

    Source sentences

    Summary
    MGF E peptide pretreatment could recover the cellular metabolic activity of MSCs reduced by 72 dyne cm(-2) FSS
    1 context sentence
    Summary · context
    MSCs were exposed to FSS for 30 min after they were pretreated with MGF E peptide for 24 h.
  2. 02LabIn vitro (cells)Activity measurement

    In bone marrow MSCs, MGF E peptide pretreatment had a synergistic effect with fluid shear stress on cellular metabolic viability at 24 and 72 dyne cm(-2).

    In plain wordsIn stem cells in a lab dish, MGF E peptide pretreatment and fluid stress together had a combined effect on cell activity.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMSC metabolic viability at 24 and 72 dyne cm(-2) FSS
    Study

    n: not reported in source

    bone marrow mesenchymal stem cells (MSCs) exposed to fluid shear stress
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 24 h pretreatmentAs given in this study.

    Source sentences

    Summary
    had a synergistic effect with FSS on the cellular metabolic viability of MSCs under 24 and 72 dyne cm(-2) FSS.
    1 context sentence
    Summary · context
    MSCs were exposed to FSS for 30 min after they were pretreated with MGF E peptide for 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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