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Study · Systematic review · 2014

2 results

Interventions to reduce haemorrhage during myomectomy for fibroids.

Kongnyuy EJ, Wiysonge CS

The Cochrane database of systematic reviews15 Aug 2014Cited by 38 (Europe PMC)

PMID25125317 (opens in a new tab)PMCIDPMC9017065 (opens in a new tab)DOI10.1002/14651858.cd005355.pub5 (opens in a new tab)PepBankPUB-25125317
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In women having myomectomy for fibroids, a meta-analysis of randomised trials found no good evidence that oxytocin reduced blood loss.

    In plain wordsIn women having surgery to remove fibroids, trials gave no good evidence that oxytocin reduced blood loss.

    Peptide
    Oxytocin
    Outcome
    No significant changeBlood loss during myomectomy
    Study

    n: not reported in source

    Comparator
    Placebo or no treatment
    Analysis
    Primary
    Outcome group
    Bleeding and clotting · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There was no good evidence of an effect on blood loss with oxytocin, morcellation or clipping of the uterine artery
    2 context sentences
    Summary · context
    We selected randomised controlled trials (RCTs) that compared potential interventions to reduce blood loss during myomectomy to placebo or no treatment.
    Summary · context
    Eighteen RCTs with 1250 participants met our inclusion criteria.
  2. 02HumanSystematic reviewEfficacy outcome

    In women having myomectomy for fibroids, a meta-analysis of randomised trials found no evidence that oxytocin reduced the need for blood transfusion.

    In plain wordsIn women having surgery to remove fibroids, trials showed no evidence that oxytocin reduced the need for blood transfusion.

    Peptide
    Oxytocin
    Outcome
    No significant changeNeed for blood transfusion during myomectomy
    Study

    n: not reported in source

    Comparator
    Placebo or no treatment
    Analysis
    Primary
    Outcome group
    Bleeding and clotting · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but no evidence of effect on the need for blood transfusion with misoprostol, oxytocin, tranexamic acid, ascorbic acid, loop ligation of the myoma pseudocapsule and a fibrin sealant patch
    2 context sentences
    Summary · context
    We selected randomised controlled trials (RCTs) that compared potential interventions to reduce blood loss during myomectomy to placebo or no treatment.
    Summary · context
    Eighteen RCTs with 1250 participants met our inclusion criteria.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials3

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

3 trials · 1 completed · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 4NCT05806307

Methods Decreasing Bleeding in Open Myomectomy

Cairo Universityn = 10515 Mar 2023 to est. 30 Nov 2023

Misoprostol Allergy · Oxytocin Allergy · Tranexamic Acid Allergy · Ethamsylate Allergy · Myoma · Blood Loss, Surgical

Trial pageClinicalTrials.govUpdated 10 Apr 2023
CompletedNot applicableNCT05517590

Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.

Acibadem Universityn = 1021 Sept 2022 to 30 Apr 2024

Leiomyoma, Uterine · Intraoperative Blood Loss

Trial pageClinicalTrials.govUpdated 24 May 2024
Status unknownPhase 4NCT04595812

Methods to Reduce Blood Loss in Abdominal Myomectomy

Cairo Universityn = 120est. 1 Nov 2020 to est. 15 Sept 2022

Abdominal Myomectomy · Blood Loss

Trial pageClinicalTrials.govUpdated 22 Oct 2020

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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