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Study · Animal study (in vivo) · rat · 2015

11 results

AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats.

Du LL, Chai DM, Zhao LN, Li XH, Zhang FC, Zhang HB, Liu LB, Wu K, Liu R, Wang JZ, Zhou XW

Journal of Alzheimer's disease : JAD1 Jan 2015Cited by 114 (Europe PMC)

PMID25114075 (opens in a new tab)DOI10.3233/jad-140564 (opens in a new tab)PepBankPUB-25114075
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated the reduction in active phosphorylated AMPK.

    In plain wordsIn rats, AICAR mitigated reduced active AMPK compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK phosphorylation
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    We found that the level of p-AMPK (active type of AMPK) and SIRT1 activity were decreased and the level of phosphorylated tau was increased at Ser396 and Thr231 sites in ICV-STZ rats when compared with control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated the reduction in SIRT1 activity.

    In plain wordsIn rats, AICAR mitigated reduced SIRT1 activity compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSIRT1 activity
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    We found that the level of p-AMPK (active type of AMPK) and SIRT1 activity were decreased and the level of phosphorylated tau was increased at Ser396 and Thr231 sites in ICV-STZ rats when compared with control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated increased tau phosphorylation at Ser396.

    In plain wordsIn rats, AICAR reduced tau phosphorylation at Ser396 compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTau phosphorylation at Ser396
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    We found that the level of p-AMPK (active type of AMPK) and SIRT1 activity were decreased and the level of phosphorylated tau was increased at Ser396 and Thr231 sites in ICV-STZ rats when compared with control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated increased tau phosphorylation at Thr231.

    In plain wordsIn rats, AICAR reduced tau phosphorylation at Thr231 compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTau phosphorylation at Thr231
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    We found that the level of p-AMPK (active type of AMPK) and SIRT1 activity were decreased and the level of phosphorylated tau was increased at Ser396 and Thr231 sites in ICV-STZ rats when compared with control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated reduced mitochondrial membrane potential.

    In plain wordsIn rats, AICAR mitigated reduced mitochondrial membrane potential compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    Mitochondria from ICV-STZ rats displayed a significant decrease in mitochondrial membrane potential, complex I activity, ATP level, and superoxide dismutase activity as well as an increase of reactive oxygen species production when compared with that from control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated reduced mitochondrial complex I activity.

    In plain wordsIn rats, AICAR mitigated reduced mitochondrial complex I activity compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMitochondrial complex I activity
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    Mitochondria from ICV-STZ rats displayed a significant decrease in mitochondrial membrane potential, complex I activity, ATP level, and superoxide dismutase activity as well as an increase of reactive oxygen species production when compared with that from control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated reduced mitochondrial ATP levels.

    In plain wordsIn rats, AICAR mitigated reduced mitochondrial ATP levels compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseATP level
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    Mitochondria from ICV-STZ rats displayed a significant decrease in mitochondrial membrane potential, complex I activity, ATP level, and superoxide dismutase activity as well as an increase of reactive oxygen species production when compared with that from control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated reduced mitochondrial superoxide dismutase activity.

    In plain wordsIn rats, AICAR mitigated reduced superoxide dismutase activity compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    Mitochondria from ICV-STZ rats displayed a significant decrease in mitochondrial membrane potential, complex I activity, ATP level, and superoxide dismutase activity as well as an increase of reactive oxygen species production when compared with that from control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated increased mitochondrial reactive oxygen species production.

    In plain wordsIn rats, AICAR reduced mitochondrial reactive oxygen species production compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseReactive oxygen species production
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    Mitochondria from ICV-STZ rats displayed a significant decrease in mitochondrial membrane potential, complex I activity, ATP level, and superoxide dismutase activity as well as an increase of reactive oxygen species production when compared with that from control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In STZ-treated rats, AICAR mitigated increased apoptotic cell numbers assessed by cleaved caspase-3 staining.

    In plain wordsIn rats, AICAR reduced apoptotic cells compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseApoptotic cells
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    2 context sentences
    Summary · context
    Meanwhile the number of apoptotic cell confirmed by cleaved caspase-3 (active type of caspase-3) staining was also stronger in ICV-STZ rats than control rats.
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-treated rats, AICAR mitigated cognitive impairment.

    In plain wordsIn rats, AICAR reduced cognitive impairment compared with vehicle after STZ.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCognitive impairment
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin-induced Alzheimer's disease model
    Comparator
    Vehicle after STZ
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    All pathological changes including biochemistry and cognitive function could be mitigated through rescuing AMPK activity with its specific activator (AICAR) in ICV-STZ rats.
    1 context sentence
    Summary · context
    Rats infused with STZ (3 mg/kg, once) were followed by injection of AICAR (AMPK activator) or vehicle via ICV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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