Intermittent administration of teriparatide enhances graft bone healing and accelerates spinal fusion in rats with glucocorticoid-induced osteoporosis.

Sugiura T, Kashii M, Matsuo Y, Morimoto T, Honda H, Kaito T, Iwasaki M, Yoshikawa H

The spine journal : official journal of the North American Spine Society7 Aug 2014Cited by 36 (Europe PMC)

PMID25110274DOI10.1016/j.spinee.2014.08.001PepBankPUB-25110274

Publisher page PubMedAsk about this study

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with glucocorticoid-induced osteoporosis, teriparatide increased fusion mass bone volume versus control at four and six weeks after surgery.
In plain wordsIn rats with osteoporosis, teriparatide increased bone volume at the spinal fusion site versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion mass bone volume
Study
ratn = 18
Glucocorticoid-induced osteoporosis with spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 μg/kg five times a week · 6 weeksAs given in this study (rat).
Source sentences
Summary
In the TPTD group, values for bone volume and other bone microstructural parameters at the fusion mass increased and peaked 4 weeks after surgery, and these values were significantly greater than those for the control (CNT) group at 4 and 6 weeks after surgery.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental animal study of rats under continuous glucocorticoid (GC) exposure undergoing spinal fusion surgery and administration of TPTD or saline.
Summary · context
Then, five times a week, they were given either saline or 40 μg/kg TPTD for 6 weeks.
Report a problemFND-2511027401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with glucocorticoid-induced osteoporosis, fusion mass microstructural parameters were greater with teriparatide than control at four and six weeks.
In plain wordsIn rats with osteoporosis, teriparatide increased bone microstructural measures at the spinal fusion site versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion mass microstructural parameters
Study
ratn = 18
Glucocorticoid-induced osteoporosis with spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 μg/kg five times a week · 6 weeksAs given in this study (rat).
Source sentences
Summary
In the TPTD group, values for bone volume and other bone microstructural parameters at the fusion mass increased and peaked 4 weeks after surgery, and these values were significantly greater than those for the control (CNT) group at 4 and 6 weeks after surgery.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental animal study of rats under continuous glucocorticoid (GC) exposure undergoing spinal fusion surgery and administration of TPTD or saline.
Summary · context
Then, five times a week, they were given either saline or 40 μg/kg TPTD for 6 weeks.
Report a problemFND-2511027402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with glucocorticoid-induced osteoporosis, spinal fusion occurred in 89% with teriparatide versus 56% with control.
In plain wordsIn rats with osteoporosis, spinal fusion was more frequent with teriparatide than control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSpinal fusion rate
Study
ratn = 18
Glucocorticoid-induced osteoporosis with spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 μg/kg five times a week · 6 weeksAs given in this study (rat).
Measurements
Fusion rate
89%
teriparatide
Fusion rate
56%
control
Source sentences
Summary
Fusion assessment showed that fusion rate was higher in the TPTD group than in the CNT group (CNT group: 56%, TPTD group: 89%).
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental animal study of rats under continuous glucocorticoid (GC) exposure undergoing spinal fusion surgery and administration of TPTD or saline.
Summary · context
Then, five times a week, they were given either saline or 40 μg/kg TPTD for 6 weeks.
Report a problemFND-2511027403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with glucocorticoid-induced osteoporosis, bone formation parameters were significantly higher with teriparatide than control.
In plain wordsIn rats with osteoporosis, teriparatide increased bone formation measures versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation parameters
Study
ratn = 18
Glucocorticoid-induced osteoporosis with spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 μg/kg five times a week · 6 weeksAs given in this study (rat).
Source sentences
Summary
Bone histomorphometry revealed that values for bone formation parameters were significantly higher in the TPTD group than in the CNT group.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental animal study of rats under continuous glucocorticoid (GC) exposure undergoing spinal fusion surgery and administration of TPTD or saline.
Summary · context
Then, five times a week, they were given either saline or 40 μg/kg TPTD for 6 weeks.
Report a problemFND-2511027404

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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Intermittent administration of teriparatide enhances graft bone healing and accelerates spinal fusion in rats with glucocorticoid-induced osteoporosis.

Summary

Results from this study4

Version history

Subjects

Publication types

MeSH terms

Keywords