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Study · In vitro (cells) · 2014

7 results

Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling.

Hartwig K, Fackler V, Jaksch-Bogensperger H, Winter S, Furtner T, Couillard-Despres S, Meier D, Moessler H, Aigner L

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2 Aug 2014Cited by 26 (Europe PMC)

PMID25093704 (opens in a new tab)DOI10.1016/j.ijdevneu.2014.07.005 (opens in a new tab)PepBankPUB-25093704
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In CoCl2-treated naive PC12 cells, cerebrolysin maintained cell diameter.

    In plain wordsIn cells, cerebrolysin maintained cell diameter during cobalt chloride exposure.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableCell diameter
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin maintained the cell-diameter of CoCl2-treated naïve PC12 cells
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.
  2. 02LabIn vitro (cells)Activity measurement

    In CoCl2-stressed naive PC12 cells, cerebrolysin decreased Caspase 3/7 activation.

    In plain wordsIn cells, cerebrolysin reduced Caspase 3/7 activation during cobalt chloride exposure.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCaspase 3/7 activation
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased the activation of Caspase 3/7 in CoCl2-stressed naïve PC12 cells
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.
  3. 03LabIn vitro (cells)Activity measurement

    In CoCl2-impaired naive PC12 cells, cerebrolysin restored metabolic activity.

    In plain wordsIn cells, cerebrolysin restored metabolic activity in naive PC12 cells impaired by cobalt chloride.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMetabolic activity in naive cells
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    restored the cells' metabolic activity in CoCl2-impaired naïve and differentiated PC12 cells.
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.
  4. 04LabIn vitro (cells)Activity measurement

    In CoCl2-impaired differentiated PC12 cells, cerebrolysin restored metabolic activity.

    In plain wordsIn cells, cerebrolysin restored metabolic activity in differentiated PC12 cells impaired by cobalt chloride.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMetabolic activity in differentiated cells
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    restored the cells' metabolic activity in CoCl2-impaired naïve and differentiated PC12 cells.
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.
  5. 05LabIn vitro (cells)Activity measurement

    In PC12 cells exposed to CoCl2, cerebrolysin decreased superoxide levels.

    In plain wordsIn cells, cerebrolysin reduced superoxide levels after cobalt chloride exposure.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSuperoxide levels
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin treatment also decreased the levels of superoxide observed after exposure to CoCl2.
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.
  6. 06LabIn vitro (cells)Mechanism

    In CoCl2-stressed PC12 cells, cerebrolysin increased GSK3β phosphorylation.

    In plain wordsIn cells, cerebrolysin increased GSK3β phosphorylation during cobalt chloride stress.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGSK3β phosphorylation
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Investigating the mechanism of action, we could demonstrate that Cerebrolysin application to CoCl2-stressed PC12 cells increased the phosphorylation of GSK3β, resulting in the inhibition of GSK3β.
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.
  7. 07LabIn vitro (cells)Mechanism

    In CoCl2-stressed PC12 cells, cerebrolysin inhibited GSK3β through increased phosphorylation.

    In plain wordsIn cells, cerebrolysin inhibited GSK3β during cobalt chloride stress.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseGSK3β activity
    Study

    n: not reported in source

    CoCl2-stressed PC12 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Investigating the mechanism of action, we could demonstrate that Cerebrolysin application to CoCl2-stressed PC12 cells increased the phosphorylation of GSK3β, resulting in the inhibition of GSK3β.
    1 context sentence
    Summary · context
    This study aimed to investigate the neuroprotective effect of Cerebrolysin in a widely used in vitro model of hypoxia-induced neuronal cytotoxicity, namely cobalt chloride (CoCl2)-treatment of PC12 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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