Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis.

Yan JY, Tian FM, Wang WY, Cheng Y, Song HP, Zhang YZ, Zhang L

Osteoarthritis and cartilage30 Jul 2014Cited by 43 (Europe PMC)

PMID25084133DOI10.1016/j.joca.2014.07.013PepBankPUB-25084133

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs with spontaneous osteoarthritis, PTH reduced OARSI scores at six and nine months of age.
In plain wordsIn guinea pigs with osteoarthritis, PTH reduced cartilage damage scores compared with saline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseOARSI cartilage damage score
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Histological analyses revealed OA occurred at 3 months of age and was more severe with increasing age, and PTH (1-34) reduced the OARSI scores at 6 and 9 months of age.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413301
02AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs with spontaneous osteoarthritis, PTH increased subchondral bone volume ratio.
In plain wordsIn guinea pigs with osteoarthritis, PTH increased bone volume ratio under cartilage compared with saline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSubchondral bone volume ratio
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Micro-CT analysis indicated that PTH (1-34) treatment increased the bone volume ratio and bone mineral density (BMD), while retarding the subchondral trabecular bone micro-architectural changes from rod-like to plate-like.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413302
03AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs with spontaneous osteoarthritis, PTH increased subchondral BMD.
In plain wordsIn guinea pigs with osteoarthritis, PTH increased bone mineral density under cartilage compared with saline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSubchondral BMD
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Micro-CT analysis indicated that PTH (1-34) treatment increased the bone volume ratio and bone mineral density (BMD), while retarding the subchondral trabecular bone micro-architectural changes from rod-like to plate-like.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413303
04AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs with spontaneous osteoarthritis, PTH retarded subchondral trabecular changes from rod-like to plate-like architecture.
In plain wordsIn guinea pigs with osteoarthritis, PTH slowed trabecular changes from rod-like to plate-like shapes compared with saline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseRod-like to plate-like trabecular changes
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Micro-CT analysis indicated that PTH (1-34) treatment increased the bone volume ratio and bone mineral density (BMD), while retarding the subchondral trabecular bone micro-architectural changes from rod-like to plate-like.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413304
05AnimalAnimal study (in vivo)Mechanism
In guinea pigs with spontaneous osteoarthritis, PTH increased cartilage type-II collagen expression versus controls.
In plain wordsIn guinea pigs with osteoarthritis, PTH increased cartilage type-II collagen expression compared with controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCartilage type-II collagen expression
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Immunohistochemical staining demonstrated that PTH (1-34) treatment increased type-II collagen expression and decreased SOST and MMP-13 expression in the cartilage, while elevating the PTH1R, OPG/RANKL expression ratio in the cartilage and subchondral trabecular bone when compared with the control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413305
06AnimalAnimal study (in vivo)Mechanism
In guinea pigs with spontaneous osteoarthritis, PTH decreased cartilage SOST expression versus controls.
In plain wordsIn guinea pigs with osteoarthritis, PTH reduced cartilage SOST expression compared with controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseCartilage SOST expression
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Immunohistochemical staining demonstrated that PTH (1-34) treatment increased type-II collagen expression and decreased SOST and MMP-13 expression in the cartilage, while elevating the PTH1R, OPG/RANKL expression ratio in the cartilage and subchondral trabecular bone when compared with the control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413306
07AnimalAnimal study (in vivo)Mechanism
In guinea pigs with spontaneous osteoarthritis, PTH decreased cartilage MMP-13 expression versus controls.
In plain wordsIn guinea pigs with osteoarthritis, PTH reduced cartilage MMP-13 expression compared with controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseCartilage MMP-13 expression
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Immunohistochemical staining demonstrated that PTH (1-34) treatment increased type-II collagen expression and decreased SOST and MMP-13 expression in the cartilage, while elevating the PTH1R, OPG/RANKL expression ratio in the cartilage and subchondral trabecular bone when compared with the control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413307
08AnimalAnimal study (in vivo)Mechanism
In guinea pigs with spontaneous osteoarthritis, PTH increased PTH1R expression in cartilage and subchondral trabecular bone versus controls.
In plain wordsIn guinea pigs with osteoarthritis, PTH increased PTH1R expression in cartilage and underlying bone compared with controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePTH1R expression
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Immunohistochemical staining demonstrated that PTH (1-34) treatment increased type-II collagen expression and decreased SOST and MMP-13 expression in the cartilage, while elevating the PTH1R, OPG/RANKL expression ratio in the cartilage and subchondral trabecular bone when compared with the control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413308
09AnimalAnimal study (in vivo)Mechanism
In guinea pigs with spontaneous osteoarthritis, PTH increased the OPG/RANKL expression ratio in cartilage and subchondral trabecular bone versus controls.
In plain wordsIn guinea pigs with osteoarthritis, PTH increased the OPG/RANKL expression ratio in cartilage and underlying bone compared with controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOPG/RANKL expression ratio
Study
guinea pign: not reported in source
Spontaneous osteoarthritis
Comparator
Normal saline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Immunohistochemical staining demonstrated that PTH (1-34) treatment increased type-II collagen expression and decreased SOST and MMP-13 expression in the cartilage, while elevating the PTH1R, OPG/RANKL expression ratio in the cartilage and subchondral trabecular bone when compared with the control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty-eight 1-month-old guinea pigs were divided into two groups: 32 were treated by normal saline (NS) and sacrificed at 1, 3, 6 and 9 months of age; the other 16 received PTH (1-34) from 3 months, and were sacrificed at 6 and 9 months.
Report a problemFND-2508413309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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