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Study · Measured the body's own peptide · 2014

2 results

Differential effects of MDMA and methylphenidate on social cognition.

Schmid Y, Hysek CM, Simmler LD, Crockett MJ, Quednow BB, Liechti ME

Journal of psychopharmacology (Oxford, England)22 Jul 2014Cited by 130 (Europe PMC)

PMID25052243 (opens in a new tab)DOI10.1177/0269881114542454 (opens in a new tab)PepBankPUB-25052243
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialMechanism

    In healthy adults, MDMA increased plasma levels of the body's own oxytocin versus placebo.

    In plain wordsIn healthy adults, MDMA raised the body's own oxytocin levels in blood compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after MDMA
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    MDMA but not methylphenidate increased the plasma levels of oxytocin and prolactin
    1 context sentence
    Summary · context
    We investigated the acute effects of MDMA (75 mg), methylphenidate (40 mg) and placebo using the Facial Emotion Recognition Task, Multifaceted Empathy Test, Movie for the Assessment of Social Cognition, Social Value Orientation Test and the Moral Judgment Task in a cross-over study in 30 healthy subjects.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialMechanism

    In healthy adults, methylphenidate did not increase plasma levels of the body's own oxytocin.

    In plain wordsIn healthy adults, methylphenidate did not raise the body's own oxytocin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin after methylphenidate
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    MDMA but not methylphenidate increased the plasma levels of oxytocin and prolactin.
    1 context sentence
    Summary · context
    We investigated the acute effects of MDMA (75 mg), methylphenidate (40 mg) and placebo using the Facial Emotion Recognition Task, Multifaceted Empathy Test, Movie for the Assessment of Social Cognition, Social Value Orientation Test and the Moral Judgment Task in a cross-over study in 30 healthy subjects.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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