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Study · In vitro (cells) · 2014

2 results

[Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging].

Khavinson VKh, Tarnovskaia SI, Lin'kova NS, Guton EO, Elashkina EV

Advances in gerontology = Uspekhi gerontologii1 Jan 2014Cited by 4 (Europe PMC)

PMID25051766 (opens in a new tab)DOI10.1134/s2079057015040116 (opens in a new tab)PepBankPUB-25051766
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cell cultures, vesugen stimulated proliferation-associated Ki-67 protein, which decreased during aging.

    In plain wordsIn cells, vesugen increased proliferation-associated Ki-67 protein.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseProliferation-associated Ki-67 protein
    Study

    n: not reported in source

    tissue-specific cultures from young and old animals and dissociated vascular endothelial cultures
    Outcome group
    Aging markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Short peptides vesugen and D-7 have stimulated proliferation-associated protein Ki-67 decreased during aging in tissue-specific cell cultures received from young and old animals and in dissociated vascular endothelial cell cultures.

Studies that did not test the peptide alone1

In this study, Vesugen (KED) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vesugen (KED).

  1. 02Computer modelNot a test of Vesugen (KED) aloneIn silicoMechanism

    In molecular docking, vesugen interacted with the MKI67 promoter region.

    In plain wordsComputer models predicted that vesugen interacted with the MKI67 promoter region.

    Peptide
    Vesugen (KED)
    Outcome
    Not applicableMKI67 promoter interaction
    Study

    n: not reported in source

    Molecular docking to MKI67 promoter
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Peptides vesugen and D-7 have interacted with promoter region of MKI67 gene coding protein Ki-67 that was obtained using methods of molecular docking.

    In this study, Vesugen (KED) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vesugen (KED).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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