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Study · Randomized controlled trial · 2014

5 results

Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.

Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz L

Fertility and sterility17 Jul 2014Cited by 49 (Europe PMC)

PMID25044085 (opens in a new tab)DOI10.1016/j.fertnstert.2014.06.004 (opens in a new tab)PepBankPUB-25044085
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In hypogonadal men, enclomiphene increased morning testosterone similarly to topical testosterone gel.

    In plain wordsIn hypogonadal men, enclomiphene raised morning testosterone similarly to testosterone gel.

    Peptide
    Enclomiphene
    Outcome
    IncreaseMorning testosterone
    Study

    n: not reported in source

    Comparator
    Topical testosterone gel
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    Treatment with enclomiphene citrate resulted in increased morning serum T, E2, and LH levels similar to those obtained with a topical T gel in men with secondary hypogonadism.
    2 context sentences
    Summary · context
    Men with secondary hypogonadism.
    Summary · context
    Oral administration of enclomiphene citrate or 1% topical T gel.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In hypogonadal men, enclomiphene increased estradiol similarly to topical testosterone gel.

    In plain wordsIn hypogonadal men, enclomiphene raised estradiol similarly to testosterone gel.

    Peptide
    Enclomiphene
    Outcome
    IncreaseEstradiol
    Study

    n: not reported in source

    Comparator
    Topical testosterone gel
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    Treatment with enclomiphene citrate resulted in increased morning serum T, E2, and LH levels similar to those obtained with a topical T gel in men with secondary hypogonadism.
    2 context sentences
    Summary · context
    Men with secondary hypogonadism.
    Summary · context
    Oral administration of enclomiphene citrate or 1% topical T gel.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In hypogonadal men, enclomiphene increased LH, with the abstract reporting increases similar to topical testosterone gel.

    In plain wordsIn hypogonadal men, enclomiphene raised LH, with increases reported as similar to testosterone gel.

    Peptide
    Enclomiphene
    Outcome
    IncreaseLH
    Study

    n: not reported in source

    Comparator
    Topical testosterone gel
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    Treatment with enclomiphene citrate resulted in increased morning serum T, E2, and LH levels similar to those obtained with a topical T gel in men with secondary hypogonadism.
    3 context sentences
    Summary · context
    Follicle-stimulating hormone and LH were increased with enclomiphene, and sperm counts were conserved.
    Summary · context
    Men with secondary hypogonadism.
    Summary · context
    Oral administration of enclomiphene citrate or 1% topical T gel.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In hypogonadal men, enclomiphene increased FSH.

    In plain wordsIn hypogonadal men, FSH rose during enclomiphene treatment.

    Peptide
    Enclomiphene
    Outcome
    IncreaseFSH
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    Follicle-stimulating hormone and LH were increased with enclomiphene, and sperm counts were conserved.
    2 context sentences
    Summary · context
    Men with secondary hypogonadism.
    Summary · context
    Oral administration of enclomiphene citrate or 1% topical T gel.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In hypogonadal men, enclomiphene conserved sperm counts.

    In plain wordsIn hypogonadal men, sperm counts remained conserved during enclomiphene treatment.

    Peptide
    Enclomiphene
    Outcome
    No significant changeSperm counts
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    Follicle-stimulating hormone and LH were increased with enclomiphene, and sperm counts were conserved.
    2 context sentences
    Summary · context
    Men with secondary hypogonadism.
    Summary · context
    Oral administration of enclomiphene citrate or 1% topical T gel.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2Results postedNCT01270841

Normalization of Morning Testosterone Levels in Men With Secondary Hypogonadism

Repros Therapeutics Inc.n = 83Jan 2011 to Dec 2011

Secondary Hypogonadism

Trial pageClinicalTrials.govUpdated 28 Jul 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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