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Study · Randomized controlled trial · n = 23 · 2014

6 results

Complexity of oxytocin׳s effects in a chronic cocaine dependent population.

Lee MR, Glassman M, King-Casas B, Kelly DL, Stein EA, Schroeder J, Salmeron BJ

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology1 Jul 2014Cited by 47 (Europe PMC)

PMID25044050 (opens in a new tab)PMCIDPMC5441556 (opens in a new tab)DOI10.1016/j.euroneuro.2014.06.005 (opens in a new tab)PepBankPUB-25044050
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent inpatients, intranasal oxytocin increased the desire to use cocaine versus placebo.

    In plain wordsIn people dependent on cocaine, oxytocin nasal spray increased the desire to use cocaine compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDesire to use cocaine
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin increased desire to use cocaine and cue-induced excitability with no effect on cue-induced desire to use.
    2 context sentences
    Summary · context
    In this double-blind, placebo-controlled crossover study, 23 cocaine-dependent inpatients in court-ordered treatment completed 4 task sessions measuring desire to use cocaine, cue-induced craving, monetary reward decisions and social cognition.
    Summary · context
    Before each session, subjects administered 24 IU of intranasal oxytocin or placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent inpatients, intranasal oxytocin increased cue-induced excitability versus placebo.

    In plain wordsIn people dependent on cocaine, oxytocin nasal spray increased excitability in response to cues compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseCue-induced excitability
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin increased desire to use cocaine and cue-induced excitability with no effect on cue-induced desire to use.
    2 context sentences
    Summary · context
    In this double-blind, placebo-controlled crossover study, 23 cocaine-dependent inpatients in court-ordered treatment completed 4 task sessions measuring desire to use cocaine, cue-induced craving, monetary reward decisions and social cognition.
    Summary · context
    Before each session, subjects administered 24 IU of intranasal oxytocin or placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent inpatients, intranasal oxytocin had no effect on cue-induced desire to use versus placebo.

    In plain wordsIn people dependent on cocaine, oxytocin nasal spray did not change cue-induced desire to use compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCue-induced desire to use
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin increased desire to use cocaine and cue-induced excitability with no effect on cue-induced desire to use.
    2 context sentences
    Summary · context
    In this double-blind, placebo-controlled crossover study, 23 cocaine-dependent inpatients in court-ordered treatment completed 4 task sessions measuring desire to use cocaine, cue-induced craving, monetary reward decisions and social cognition.
    Summary · context
    Before each session, subjects administered 24 IU of intranasal oxytocin or placebo.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent inpatients, intranasal oxytocin removed the effect of state anger on several measures of cue reactivity.

    In plain wordsIn people dependent on cocaine, oxytocin nasal spray removed the effect of anger on several measures of reaction to cues.

    Peptide
    Oxytocin
    Outcome
    DecreaseEffect of state anger on cue reactivity
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin also removed the effect of state anger on several measures of cue reactivity.
    2 context sentences
    Summary · context
    In this double-blind, placebo-controlled crossover study, 23 cocaine-dependent inpatients in court-ordered treatment completed 4 task sessions measuring desire to use cocaine, cue-induced craving, monetary reward decisions and social cognition.
    Summary · context
    Before each session, subjects administered 24 IU of intranasal oxytocin or placebo.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent inpatients, response to monetary reward increased under intranasal oxytocin versus placebo.

    In plain wordsIn people dependent on cocaine, response to money rewards increased under oxytocin nasal spray compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseResponse to monetary reward
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Response to monetary reward increased under oxytocin
    2 context sentences
    Summary · context
    In this double-blind, placebo-controlled crossover study, 23 cocaine-dependent inpatients in court-ordered treatment completed 4 task sessions measuring desire to use cocaine, cue-induced craving, monetary reward decisions and social cognition.
    Summary · context
    Before each session, subjects administered 24 IU of intranasal oxytocin or placebo.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent inpatients, measures of social cognition worsened under intranasal oxytocin versus placebo.

    In plain wordsIn people dependent on cocaine, social cognition scores got worse under oxytocin nasal spray compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSocial cognition measures
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    measures of social cognition worsened.
    2 context sentences
    Summary · context
    In this double-blind, placebo-controlled crossover study, 23 cocaine-dependent inpatients in court-ordered treatment completed 4 task sessions measuring desire to use cocaine, cue-induced craving, monetary reward decisions and social cognition.
    Summary · context
    Before each session, subjects administered 24 IU of intranasal oxytocin or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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