Protein profiling reveals antioxidant and signaling activities of NAP (Davunetide) in rodent hippocampus exposed to hypobaric hypoxia.

Sethy NK, Sharma NK, Das M, Bhargava K

Journal of molecular neuroscience : MN20 Jul 2014Cited by 4 (Europe PMC)

PMID25038875DOI10.1007/s12031-014-0381-9PepBankPUB-25038875

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In hypoxic rat hippocampus, NAP supplementation was associated with altered expression of 80 proteins.
In plain wordsIn rats under low oxygen, 80 hippocampal proteins showed altered expression with NAP supplementation.
Peptide
Davunetide
Outcome
Direction not reportedHippocampal protein expression profile
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Altered proteins
80 proteins
NAP-supplemented hippocampus after hypoxia
Source sentences
Summary
Using 2D-gel electrophoresis (2D-GE) with matrix-assisted laser desorption ionization time of flight (MALDI-TOF/TOF) mass spectrometry, we have identified altered expression of 80 proteins in NAP-supplemented hippocampus after hypoxia.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887501
02AnimalAnimal study (in vivo)Mechanism
In hypoxic rat hippocampus, NAP supplementation significantly regulated oxidative stress response, oxidoreductase activity, and cellular response to stress pathways.
In plain wordsIn hypoxic rat hippocampus, NAP supplementation significantly regulated oxidative stress response, oxidoreductase activity, and cellular response to stress pathways.
Peptide
Davunetide
Outcome
Direction not reportedRegulation of stress-response pathways
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pathway analysis revealed that NAP supplementation significantly regulated oxidative stress response, oxidoreductase activity and cellular response to stress pathways during hypoxia.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887502
03AnimalAnimal study (in vivo)Mechanism
In hypoxic rat hippocampus, NAP supplementation regulated energy production, AMPK signaling, and Rho family GTPase signaling pathways.
In plain wordsIn hypoxic rat hippocampus, NAP supplementation regulated energy production, AMPK signaling, and Rho family GTPase signaling pathways.
Peptide
Davunetide
Outcome
Direction not reportedRegulation of energy-production, AMPK, and Rho signaling pathways
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Additionally, NAP supplementation also regulated energy production pathways along with AMP-activated protein kinase (AMPK) signaling and signaling by Rho family GTPases pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887503
04AnimalAnimal study (in vivo)Mechanism
In NAP-supplemented hypoxic rat hippocampus, Sod1 protein expression was higher.
In plain wordsIn rats under low oxygen, hippocampal Sod1 protein expression was higher with NAP supplementation.
Peptide
Davunetide
Outcome
IncreaseSod1 protein expression
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We observed higher expression of antioxidant Sod1, Eno1, Prdx2 and Prdx5 proteins that were subsequently validated by Western blotting.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887504
05AnimalAnimal study (in vivo)Mechanism
In NAP-supplemented hypoxic rat hippocampus, Eno1 protein expression was higher.
In plain wordsIn rats under low oxygen, hippocampal Eno1 protein expression was higher with NAP supplementation.
Peptide
Davunetide
Outcome
IncreaseEno1 protein expression
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We observed higher expression of antioxidant Sod1, Eno1, Prdx2 and Prdx5 proteins that were subsequently validated by Western blotting.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887505
06AnimalAnimal study (in vivo)Mechanism
In NAP-supplemented hypoxic rat hippocampus, Prdx2 protein expression was higher by Western blotting and immunohistochemistry.
In plain wordsIn rats under low oxygen, hippocampal Prdx2 protein expression was higher with NAP supplementation.
Peptide
Davunetide
Outcome
IncreasePrdx2 protein expression
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We observed higher expression of antioxidant Sod1, Eno1, Prdx2 and Prdx5 proteins that were subsequently validated by Western blotting.
2 context sentences(design, population, supporting numbers)
Summary · context
A higher level of Prdx2 was also observed by immunohistochemistry in NAP-supplemented hippocampus during hypoxia.
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887506
07AnimalAnimal study (in vivo)Mechanism
In NAP-supplemented hypoxic rat hippocampus, Prdx5 protein expression was higher.
In plain wordsIn rats under low oxygen, hippocampal Prdx5 protein expression was higher with NAP supplementation.
Peptide
Davunetide
Outcome
IncreasePrdx5 protein expression
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We observed higher expression of antioxidant Sod1, Eno1, Prdx2 and Prdx5 proteins that were subsequently validated by Western blotting.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887507
08AnimalAnimal study (in vivo)Mechanism
In NAP-supplemented hypoxic rat hippocampus, protein carbonyl levels were significantly lower.
In plain wordsIn rats under low oxygen, hippocampal protein carbonyl levels were lower with NAP supplementation.
Peptide
Davunetide
Outcome
DecreaseProtein carbonyl levels
Study
ratn: not reported in source
hippocampus exposed to hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In corroboration, we are able to detect significant lower level of protein carbonyls in NAP-supplemented hypoxic hippocampus suggesting amelioration of oxidant molecules by NAP supplementation.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have evaluated the antioxidant activities of NAP in rat hippocampus exposed to hypobaric hypoxia (25,000 ft, 282 mm Hg) for 3, 6 and 12 h respectively.
Report a problemFND-2503887508

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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