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Study · Not a test of the peptide alone · 2014

1 result

Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin.

Mohammed YH, Yamada M, Lin LL, Grice JE, Roberts MS, Raphael AP, Benson HA, Prow TW

PloS one17 Jul 2014Cited by 65 (Europe PMC)

PMID25033398 (opens in a new tab)PMCIDPMC4102460 (opens in a new tab)DOI10.1371/journal.pone.0101956 (opens in a new tab)PepBankPUB-25033398
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Summary

Peptides and proteins play an important role in skin health and well-being. They are also found to contribute to skin aging and melanogenesis. Microneedles have been shown to substantially enhance skin penetration and may offer an effective means of peptide delivery enhancement. The aim of this investigation was to assess the influence of microneedles on the skin penetration of peptides using fluorescence imaging to determine skin distribution. In particular the effect of peptide chain length (3, 4, 5 amino acid chain length) on passive and MN facilitated skin penetration was investigated. Confocal laser scanning microscopy was used to image fluorescence intensity and the area of penetration of fluorescently tagged peptides. Penetration studies were conducted on excised full thickness human skin in Franz type diffusion cells for 1 and 24 hours. A 2 to 22 fold signal improvement in microneedle enhanced delivery of melanostatin, rigin and pal-KTTKS was observed. To our knowledge this is the first description of microneedle enhanced skin permeation studies on these peptides.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

  1. 01LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneEx vivo tissueOther

    In excised human skin, microneedles increased delivery signal for pooled fluorescently tagged melanostatin, rigin and pal-KTTKS versus passive delivery.

    In plain wordsIn lab tests on human skin, microneedles increased delivery signals for pooled tagged peptides, including pal-KTTKS, compared with passive delivery.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    IncreaseSkin delivery fluorescence signal
    Study

    humann: not reported in source

    Excised full thickness human skin
    Comparator
    Passive delivery
    Outcome group
    Pharmacokinetics · Skin and wound

    Measurements

    Signal improvement
    2 to 22 fold
    microneedle delivery of melanostatin, rigin and pal-KTTKS

    Source sentences

    Summary
    A 2 to 22 fold signal improvement in microneedle enhanced delivery of melanostatin, rigin and pal-KTTKS was observed.
    3 context sentences
    Summary · context
    In particular the effect of peptide chain length (3, 4, 5 amino acid chain length) on passive and MN facilitated skin penetration was investigated.
    Summary · context
    Confocal laser scanning microscopy was used to image fluorescence intensity and the area of penetration of fluorescently tagged peptides.
    Summary · context
    Penetration studies were conducted on excised full thickness human skin in Franz type diffusion cells for 1 and 24 hours.

    In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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