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Study · Randomized controlled trial · n = 18 · 2015

3 results

Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder.

Gorka SM, Fitzgerald DA, Labuschagne I, Hosanagar A, Wood AG, Nathan PJ, Phan KL

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology7 Jul 2014Cited by 107 (Europe PMC)

PMID24998619 (opens in a new tab)PMCIDPMC4443941 (opens in a new tab)DOI10.1038/npp.2014.168 (opens in a new tab)PepBankPUB-24998619
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy controls, intranasal oxytocin did not enhance amygdala functional connectivity during fearful face processing versus placebo.

    In plain wordsIn healthy adults without social anxiety, oxytocin did not strengthen amygdala brain links while viewing fearful faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmygdala connectivity during fearful faces, healthy controls
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · single acute administrationAs given in this study (human).

    Source sentences

    Summary
    Results indicated that within individuals with GSAD, but not HCs
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo (PBO)-controlled, within-subjects design, 18 HCs and 17 GSAD subjects performed a functional magnetic resonance imaging task designed to probe amygdala response to fearful faces following acute intranasal administration of PBO or OXT.
  2. 02HumanRandomized controlled trialMechanism

    In adults with generalized social anxiety disorder, intranasal oxytocin enhanced functional connectivity between the amygdala and the bilateral insula during fearful face processing versus placebo.

    In plain wordsIn adults with social anxiety disorder, oxytocin strengthened brain links between the amygdala and insula while viewing fearful faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala to insula connectivity during fearful faces, GSAD
    Study

    n = 17

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · single acute administrationAs given in this study (human).

    Source sentences

    Summary
    Results indicated that within individuals with GSAD, but not HCs, OXT enhanced functional connectivity between the amygdala and the bilateral insula and middle cingulate/dorsal anterior cingulate gyrus during the processing of fearful faces.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo (PBO)-controlled, within-subjects design, 18 HCs and 17 GSAD subjects performed a functional magnetic resonance imaging task designed to probe amygdala response to fearful faces following acute intranasal administration of PBO or OXT.
  3. 03HumanRandomized controlled trialMechanism

    In adults with generalized social anxiety disorder, intranasal oxytocin enhanced functional connectivity between the amygdala and the middle cingulate/dorsal anterior cingulate gyrus during fearful face processing versus placebo.

    In plain wordsIn adults with social anxiety disorder, oxytocin strengthened brain links between the amygdala and the cingulate while viewing fearful faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala to middle cingulate/dorsal anterior cingulate connectivity during fearful faces, GSAD
    Study

    n = 17

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · single acute administrationAs given in this study (human).

    Source sentences

    Summary
    Results indicated that within individuals with GSAD, but not HCs, OXT enhanced functional connectivity between the amygdala and the bilateral insula and middle cingulate/dorsal anterior cingulate gyrus during the processing of fearful faces.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo (PBO)-controlled, within-subjects design, 18 HCs and 17 GSAD subjects performed a functional magnetic resonance imaging task designed to probe amygdala response to fearful faces following acute intranasal administration of PBO or OXT.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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