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Study · Ex vivo tissue · 2014

10 results

Effects of cerebrolysin on motor-neuron-like NSC-34 cells.

Keilhoff G, Lucas B, Pinkernelle J, Steiner M, Fansa H

Experimental cell research2 Jul 2014Cited by 17 (Europe PMC)

PMID24997385 (opens in a new tab)DOI10.1016/j.yexcr.2014.06.020 (opens in a new tab)PepBankPUB-24997385
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In organotypic spinal cord cultures, cerebrolysin did not support motor neuron survival.

    In plain wordsIn lab tests, cerebrolysin did not support motor neuron survival in spinal cord cultures.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeMotor neuron survival
    Study

    n: not reported in source

    Organotypic spinal cord slice cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In organotypic spinal cord slice cultures, CL was not able to support motor neuron survival/neurite sprouting.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  2. 02LabEx vivo tissueActivity measurement

    In organotypic spinal cord cultures, cerebrolysin did not support neurite sprouting.

    In plain wordsIn lab tests, cerebrolysin did not support neurite sprouting in spinal cord cultures.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNeurite sprouting
    Study

    n: not reported in source

    Organotypic spinal cord slice cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In organotypic spinal cord slice cultures, CL was not able to support motor neuron survival/neurite sprouting.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  3. 03LabEx vivo tissueActivity measurement

    In organotypic spinal cord cultures, cerebrolysin hampered astroglial activity.

    In plain wordsIn lab tests, cerebrolysin reduced astroglial activity in spinal cord cultures.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAstroglial activity
    Study

    n: not reported in source

    Organotypic spinal cord slice cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, it hampered astroglia and microglia activities.
    2 context sentences
    Summary · context
    In organotypic spinal cord slice cultures, CL was not able to support motor neuron survival/neurite sprouting.
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  4. 04LabEx vivo tissueActivity measurement

    In organotypic spinal cord cultures, cerebrolysin hampered microglial activity.

    In plain wordsIn lab tests, cerebrolysin reduced microglial activity in spinal cord cultures.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMicroglial activity
    Study

    n: not reported in source

    Organotypic spinal cord slice cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, it hampered astroglia and microglia activities.
    2 context sentences
    Summary · context
    In organotypic spinal cord slice cultures, CL was not able to support motor neuron survival/neurite sprouting.
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  5. 05LabIn vitro (cells)Activity measurement

    In OGD-stressed NSC-34 cells, cerebrolysin temporarily inhibited proliferation.

    In plain wordsIn cells, cerebrolysin temporarily reduced proliferation after oxygen glucose deprivation.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCell proliferation
    Study

    n: not reported in source

    OGD-stressed NSC-34 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    CL had a temporary anti-proliferative but initially neuroprotective effect on OGD-stressed NSC-34 cells.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  6. 06LabIn vitro (cells)Activity measurement

    In OGD-stressed NSC-34 cells, cerebrolysin initially showed a neuroprotective effect.

    In plain wordsIn cells, cerebrolysin initially showed a protective effect after oxygen glucose deprivation.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseInitial neuroprotection
    Study

    n: not reported in source

    OGD-stressed NSC-34 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    CL had a temporary anti-proliferative but initially neuroprotective effect on OGD-stressed NSC-34 cells.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  7. 07LabIn vitro (cells)Safety outcome

    In NSC-34 cells, high-dose or repeated cerebrolysin application impaired cell survival.

    In plain wordsIn cells, high doses or repeated application of cerebrolysin reduced survival.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCell survival with high or repeated exposure
    Study

    n: not reported in source

    OGD-stressed NSC-34 cells
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    High-dosed or repeatedly applied CL was deleterious for cell survival.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  8. 08LabIn vitro (cells)Activity measurement

    In NSC-34 cells, cerebrolysin amplified neurite reconstruction to a limited extent.

    In plain wordsIn cells, cerebrolysin increased neurite reconstruction to a limited extent.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeurite reconstruction
    Study

    n: not reported in source

    OGD-stressed NSC-34 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    CL amplified neurite reconstruction to limited extent, affected calpain-1 protein expression and influenced calpain-mediated spectrin cleavage as a function of Src expression.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  9. 09LabIn vitro (cells)Mechanism

    In NSC-34 cells, cerebrolysin affected calpain-1 protein expression without a reported direction.

    In plain wordsIn cells, cerebrolysin affected calpain-1 protein expression, but the direction was not reported.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedCalpain-1 protein expression
    Study

    n: not reported in source

    OGD-stressed NSC-34 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    CL amplified neurite reconstruction to limited extent, affected calpain-1 protein expression and influenced calpain-mediated spectrin cleavage as a function of Src expression.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.
  10. 10LabIn vitro (cells)Mechanism

    In NSC-34 cells, cerebrolysin influenced calpain-mediated spectrin cleavage as a function of Src expression.

    In plain wordsIn cells, cerebrolysin affected spectrin cleavage in relation to Src expression.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedCalpain-mediated spectrin cleavage
    Study

    n: not reported in source

    OGD-stressed NSC-34 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    CL amplified neurite reconstruction to limited extent, affected calpain-1 protein expression and influenced calpain-mediated spectrin cleavage as a function of Src expression.
    1 context sentence
    Summary · context
    As a potential means of augmenting nerve regeneration, the effects of cerebrolysin (CL)--a proteolytic peptide fraction--were tested in vitro on the motor-neuron-like NSC-34 cell line and organotypic spinal cord cultures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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