Additive effect of PTH (1-34) and zoledronate in the prevention of disuse osteopenia in rats.

Vegger JB, Nielsen ES, Brüel A, Thomsen JS

Bone24 Jun 2014Cited by 33 (Europe PMC)

PMID24970039DOI10.1016/j.bone.2014.06.020PepBankPUB-24970039

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH increased femoral trabecular bone volume fraction by 31% versus BTX alone.
In plain wordsIn immobilized rats, PTH increased femoral trabecular bone volume fraction by 31% compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral trabecular bone volume fraction
Study
ratn: not reported in source
Botox-induced hindlimb immobilization
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 μg/kg, 5 days/week · 4 weeksAs given in this study (rat).
Source sentences
Summary
BTX+PTH resulted in higher femoral BV/TV (+31%, p<0.05), higher tibial trabecular BFR/BS (+297%, p<0.05), and higher Fmax at the distal femur (+11%, p<0.05) compared with BTX.
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two 16-week-old female Wistar rats were randomized into 6 groups; baseline (Base), control (Ctrl), BTX, BTX+PTH, BTX+Zln, and BTX+PTH+Zln.
Summary · context
PTH (1-34) (80μg/kg) was given 5days/week and Zln (100μg/kg) was given once at study start.
Summary · context
The animals were killed after 4weeks of treatment.
Report a problemFND-2497003901
02AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH increased tibial trabecular bone formation rate by 297% versus BTX alone.
In plain wordsIn immobilized rats, PTH increased tibial trabecular bone formation rate by 297% compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTibial trabecular bone formation rate
Study
ratn: not reported in source
Botox-induced hindlimb immobilization
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 μg/kg, 5 days/week · 4 weeksAs given in this study (rat).
Source sentences
Summary
BTX+PTH resulted in higher femoral BV/TV (+31%, p<0.05), higher tibial trabecular BFR/BS (+297%, p<0.05), and higher Fmax at the distal femur (+11%, p<0.05) compared with BTX.
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two 16-week-old female Wistar rats were randomized into 6 groups; baseline (Base), control (Ctrl), BTX, BTX+PTH, BTX+Zln, and BTX+PTH+Zln.
Summary · context
PTH (1-34) (80μg/kg) was given 5days/week and Zln (100μg/kg) was given once at study start.
Summary · context
The animals were killed after 4weeks of treatment.
Report a problemFND-2497003902
03AnimalAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH increased distal femoral strength by 11% versus BTX alone.
In plain wordsIn immobilized rats, PTH increased distal femoral strength by 11% compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseDistal femoral strength
Study
ratn: not reported in source
Botox-induced hindlimb immobilization
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 μg/kg, 5 days/week · 4 weeksAs given in this study (rat).
Source sentences
Summary
BTX+PTH resulted in higher femoral BV/TV (+31%, p<0.05), higher tibial trabecular BFR/BS (+297%, p<0.05), and higher Fmax at the distal femur (+11%, p<0.05) compared with BTX.
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two 16-week-old female Wistar rats were randomized into 6 groups; baseline (Base), control (Ctrl), BTX, BTX+PTH, BTX+Zln, and BTX+PTH+Zln.
Summary · context
PTH (1-34) (80μg/kg) was given 5days/week and Zln (100μg/kg) was given once at study start.
Summary · context
The animals were killed after 4weeks of treatment.
Report a problemFND-2497003903

Studies that did not test the peptide alone3

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

04AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH plus zoledronate increased femoral trabecular bone volume fraction by 70% versus BTX alone.
In plain wordsIn immobilized rats, PTH plus zoledronate increased femoral trabecular bone volume fraction by 70% compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination femoral trabecular bone volume fraction
Study
ratn: not reported in source
Botox-induced hindlimb immobilization
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
BTX+PTH+Zln resulted in higher femoral BV/TV (+70%, p<0.001), higher tibial trabecular BFR/BS (+59%, p<0.05), and higher Fmax at the distal femur (+32%, p<0.001) compared with BTX.
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two 16-week-old female Wistar rats were randomized into 6 groups; baseline (Base), control (Ctrl), BTX, BTX+PTH, BTX+Zln, and BTX+PTH+Zln.
Summary · context
PTH (1-34) (80μg/kg) was given 5days/week and Zln (100μg/kg) was given once at study start.
Summary · context
The animals were killed after 4weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2497003904
05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH plus zoledronate increased tibial trabecular bone formation rate by 59% versus BTX alone.
In plain wordsIn immobilized rats, PTH plus zoledronate increased tibial trabecular bone formation rate by 59% compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination tibial trabecular bone formation rate
Study
ratn: not reported in source
Botox-induced hindlimb immobilization
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
BTX+PTH+Zln resulted in higher femoral BV/TV (+70%, p<0.001), higher tibial trabecular BFR/BS (+59%, p<0.05), and higher Fmax at the distal femur (+32%, p<0.001) compared with BTX.
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two 16-week-old female Wistar rats were randomized into 6 groups; baseline (Base), control (Ctrl), BTX, BTX+PTH, BTX+Zln, and BTX+PTH+Zln.
Summary · context
PTH (1-34) (80μg/kg) was given 5days/week and Zln (100μg/kg) was given once at study start.
Summary · context
The animals were killed after 4weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2497003905
06AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In immobilized rats, PTH plus zoledronate increased distal femoral strength by 32% versus BTX alone.
In plain wordsIn immobilized rats, PTH plus zoledronate increased distal femoral strength by 32% compared with BTX alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination distal femoral strength
Study
ratn: not reported in source
Botox-induced hindlimb immobilization
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
BTX+PTH+Zln resulted in higher femoral BV/TV (+70%, p<0.001), higher tibial trabecular BFR/BS (+59%, p<0.05), and higher Fmax at the distal femur (+32%, p<0.001) compared with BTX.
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two 16-week-old female Wistar rats were randomized into 6 groups; baseline (Base), control (Ctrl), BTX, BTX+PTH, BTX+Zln, and BTX+PTH+Zln.
Summary · context
PTH (1-34) (80μg/kg) was given 5days/week and Zln (100μg/kg) was given once at study start.
Summary · context
The animals were killed after 4weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2497003906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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