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Study · Randomized controlled trial · n = 86 · 2014

4 results

Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: a prospective study.

Zhang X, Zou M, Zhang C, He J, Mao S, Wu Q, He M, Wang J, Zhang R, Zhang L

European journal of radiology17 May 2014Cited by 25 (Europe PMC)

PMID24951357 (opens in a new tab)DOI10.1016/j.ejrad.2014.05.008 (opens in a new tab)PepBankPUB-24951357
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with adenomyosis treated with HIFU, adding oxytocin gave a higher non-perfused volume ratio than saline.

    In plain wordsIn patients with adenomyosis treated with focused ultrasound, adding oxytocin gave a larger treated area than saline.

    Peptide
    Oxytocin
    Outcome
    IncreaseNon-perfused volume ratio
    Study

    n = 86

    Comparator
    Normal saline
    Outcome group
    Uterine fibroid outcomes · Reproductive and sexual health
    Studied dose
    80 units in 500 ml saline at 0.32 U/minAs given in this study (human).

    Measurements

    NPV ratio
    80.7%
    oxytocin
    NPV ratio
    70.8%
    control

    Source sentences

    Summary
    When using oxytocin, the non-perfused volume (NPV) ratio was 80.7±11.6%, the energy-efficiency factor (EEF) was 8.1±9.9J/mm(3), and the sonication time required to ablate 1cm(3) was 30.0±36.0s/cm(3).
    3 context sentences
    Summary · context
    When not using oxytocin, the non-perfused volume ratio was 70.8±16.7%, the EEF was 15.8±19.6J/mm(3), and the sonication time required to ablate 1cm(3) was 58.2±72.7S/cm(3).
    Summary · context
    Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1cm(3) between the two groups was observed.
    Summary · context
    Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with adenomyosis treated with HIFU, adding oxytocin lowered the energy-efficiency factor (energy needed per volume ablated) compared with saline.

    In plain wordsIn patients with adenomyosis treated with focused ultrasound, adding oxytocin reduced the energy needed to treat tissue compared with saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseEnergy-efficiency factor
    Study

    n = 86

    Comparator
    Normal saline
    Outcome group
    Uterine fibroid outcomes · Reproductive and sexual health
    Studied dose
    80 units in 500 ml saline at 0.32 U/minAs given in this study (human).

    Measurements

    EEF
    8.1 J/mm(3)
    oxytocin
    EEF
    15.8 J/mm(3)
    control

    Source sentences

    Summary
    When using oxytocin, the non-perfused volume (NPV) ratio was 80.7±11.6%, the energy-efficiency factor (EEF) was 8.1±9.9J/mm(3), and the sonication time required to ablate 1cm(3) was 30.0±36.0s/cm(3).
    3 context sentences
    Summary · context
    When not using oxytocin, the non-perfused volume ratio was 70.8±16.7%, the EEF was 15.8±19.6J/mm(3), and the sonication time required to ablate 1cm(3) was 58.2±72.7S/cm(3).
    Summary · context
    Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1cm(3) between the two groups was observed.
    Summary · context
    Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with adenomyosis treated with HIFU, adding oxytocin shortened the sonication time needed to ablate 1 cm3 compared with saline.

    In plain wordsIn patients with adenomyosis treated with focused ultrasound, adding oxytocin shortened the treatment time per volume compared with saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseSonication time to ablate 1 cm3
    Study

    n = 86

    Comparator
    Normal saline
    Outcome group
    Uterine fibroid outcomes · Reproductive and sexual health
    Studied dose
    80 units in 500 ml saline at 0.32 U/minAs given in this study (human).

    Measurements

    sonication time per cm3
    30 s/cm(3)
    oxytocin
    sonication time per cm3
    58.2 s/cm(3)
    control

    Source sentences

    Summary
    When using oxytocin, the non-perfused volume (NPV) ratio was 80.7±11.6%, the energy-efficiency factor (EEF) was 8.1±9.9J/mm(3), and the sonication time required to ablate 1cm(3) was 30.0±36.0s/cm(3).
    3 context sentences
    Summary · context
    When not using oxytocin, the non-perfused volume ratio was 70.8±16.7%, the EEF was 15.8±19.6J/mm(3), and the sonication time required to ablate 1cm(3) was 58.2±72.7S/cm(3).
    Summary · context
    Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1cm(3) between the two groups was observed.
    Summary · context
    Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment.
  4. 04HumanRandomized controlled trialSafety outcome

    In patients with adenomyosis treated with HIFU, no oxytocin-related adverse effects occurred.

    In plain wordsIn patients with adenomyosis treated with focused ultrasound, no side effects linked to oxytocin occurred.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin-related adverse effects
    Study

    n = 86

    Comparator
    Normal saline
    Outcome group
    Adverse events · Whole body
    Studied dose
    80 units in 500 ml saline at 0.32 U/minAs given in this study (human).

    Source sentences

    Summary
    No oxytocin related adverse effects occurred.
    1 context sentence
    Summary · context
    Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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