The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats.

Monge-Roffarello B, Labbe SM, Roy MC, Lemay ML, Coneggo E, Samson P, Lanfray D, Richard D

Endocrinology20 Jun 2014Cited by 21 (Europe PMC)

PMID24949658DOI10.1210/en.2013-2092PepBankPUB-24949658

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone14

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

01AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome
In rats, delta9-THC blunted the effect of MTII on energy expenditure.
In plain wordsIn rats, THC weakened the rise in energy expenditure caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII effect on energy expenditure with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC blunted the effects of MTII on energy expenditure
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965801
02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome
In rats, delta9-THC blunted the effect of MTII on interscapular brown adipose tissue temperature.
In plain wordsIn rats, THC weakened the rise in brown fat temperature caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII effect on iBAT temperature with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC blunted the effects of MTII on energy expenditure and iBAT temperature
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965802
03AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome
In rats, the CB1 antagonist AM251 tended to potentiate the effect of MTII on energy expenditure, without a clear significant change.
In plain wordsIn rats, a CB1-blocking drug tended to strengthen the energy expenditure effect of melanotan II, but the effect was not clear.
Peptide
Melanotan II
Outcome
No significant changeMTII effect on energy expenditure with AM251
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
whereas AM251 tended to potentiate the MTII effects.
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965803
04AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome
In rats, the CB1 antagonist AM251 tended to potentiate the effect of MTII on iBAT temperature, without a clear significant change.
In plain wordsIn rats, a CB1-blocking drug tended to strengthen the brown fat temperature effect of melanotan II, but the effect was not clear.
Peptide
Melanotan II
Outcome
No significant changeMTII effect on iBAT temperature with AM251
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
whereas AM251 tended to potentiate the MTII effects.
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965804
05AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC blocked the stimulating effect of MTII on 14C-bromopalmitate uptake in interscapular brown adipose tissue.
In plain wordsIn rats, THC blocked the rise in fat uptake in brown fat caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII-stimulated 14C-bromopalmitate uptake in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC also blocked the stimulating effect of MTII on (14)C-bromopalmitate and (3)H-deoxyglucose uptakes in iBAT
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965805
06AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC blocked the stimulating effect of MTII on 3H-deoxyglucose uptake in interscapular brown adipose tissue.
In plain wordsIn rats, THC blocked the rise in sugar uptake in brown fat caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII-stimulated 3H-deoxyglucose uptake in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC also blocked the stimulating effect of MTII on (14)C-bromopalmitate and (3)H-deoxyglucose uptakes in iBAT.
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965806
07AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC attenuated the stimulating effect of MTII on Pgc1a expression in brown fat.
In plain wordsIn rats, THC weakened the rise in a brown fat gene (Pgc1a) caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII-stimulated Pgc1a expression in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
Additionally, δ(9)-THC attenuated the stimulating effect of MTII on the expression of peroxisome proliferator-activated receptor-γ coactivator 1-α (Pgc1α), type II iodothyronine deiodinase (Dio2), carnitine palmitoyltransferase 1B (Cpt1b), and uncoupling protein 1 (Ucp1).
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965807
08AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC attenuated the stimulating effect of MTII on Dio2 expression in brown fat.
In plain wordsIn rats, THC weakened the rise in a brown fat gene (Dio2) caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII-stimulated Dio2 expression in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
Additionally, δ(9)-THC attenuated the stimulating effect of MTII on the expression of peroxisome proliferator-activated receptor-γ coactivator 1-α (Pgc1α), type II iodothyronine deiodinase (Dio2), carnitine palmitoyltransferase 1B (Cpt1b), and uncoupling protein 1 (Ucp1).
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965808
09AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC attenuated the stimulating effect of MTII on Cpt1b expression in brown fat.
In plain wordsIn rats, THC weakened the rise in a brown fat gene (Cpt1b) caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII-stimulated Cpt1b expression in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
Additionally, δ(9)-THC attenuated the stimulating effect of MTII on the expression of peroxisome proliferator-activated receptor-γ coactivator 1-α (Pgc1α), type II iodothyronine deiodinase (Dio2), carnitine palmitoyltransferase 1B (Cpt1b), and uncoupling protein 1 (Ucp1).
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965809
10AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC attenuated the stimulating effect of MTII on Ucp1 expression in brown fat.
In plain wordsIn rats, THC weakened the rise in a brown fat gene (Ucp1) caused by melanotan II.
Peptide
Melanotan II
Outcome
DecreaseMTII-stimulated Ucp1 expression in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
Additionally, δ(9)-THC attenuated the stimulating effect of MTII on the expression of peroxisome proliferator-activated receptor-γ coactivator 1-α (Pgc1α), type II iodothyronine deiodinase (Dio2), carnitine palmitoyltransferase 1B (Cpt1b), and uncoupling protein 1 (Ucp1).
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965810
11AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome
In rats given MTII in the paraventricular hypothalamic nucleus, delta9-THC in the fourth ventricle blunted the MTII-induced iBAT temperature elevation.
In plain wordsIn rats, THC blunted the brown fat warming caused by melanotan II given in a hypothalamic area.
Peptide
Melanotan II
Outcome
DecreasePVH MTII-induced iBAT temperature elevation with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
We demonstrated the ability of δ(9)-THC to blunt MTII-induced iBAT temperature elevation.
2 context sentences(design, population, supporting numbers)
Summary · context
In a second series of experiments, we addressed the involvement of the paraventricular hypothalamic nucleus (PVH) in the CB1-mediated effects of MTII on iBAT thermogenesis, which were assessed following the infusion of MTII in the PVH and δ(9)-THC or AM251 in the fourth ventricle of the brain.
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965811
12AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC blocked the PVH effect of MTII on 14C-bromopalmitate uptake in iBAT.
In plain wordsIn rats, THC blocked the fat-uptake effect of melanotan II given in a hypothalamic area.
Peptide
Melanotan II
Outcome
DecreasePVH MTII effect on 14C-bromopalmitate uptake in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC also blocked the PVH effect of MTII on (14)C-bromopalmitate uptake
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965812
13AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC blocked the PVH effect of MTII on Pgc1a expression in iBAT.
In plain wordsIn rats, THC blocked the effect of hypothalamic melanotan II on a brown fat gene (Pgc1a).
Peptide
Melanotan II
Outcome
DecreasePVH MTII effect on Pgc1a expression in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC also blocked the PVH effect of MTII on (14)C-bromopalmitate uptake as well as on Pgc1α and Dio2 expression in iBAT.
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965813
14AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism
In rats, delta9-THC blocked the PVH effect of MTII on Dio2 expression in iBAT.
In plain wordsIn rats, THC blocked the effect of hypothalamic melanotan II on a brown fat gene (Dio2).
Peptide
Melanotan II
Outcome
DecreasePVH MTII effect on Dio2 expression in iBAT with THC
Study
ratn: not reported in source
Comparator
MTII alone
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Source sentences
Summary
δ(9)-THC also blocked the PVH effect of MTII on (14)C-bromopalmitate uptake as well as on Pgc1α and Dio2 expression in iBAT.
1 context sentence(design, population, supporting numbers)
Summary · context
In a first series of experiments, whole-body and BAT thermogenesis were investigated in rats infused in the third ventricle of the brain with the MC4R agonist melanotan II (MTII) and the CB1 agonist δ9-tetrahydrocannabinol (δ(9)-THC) or the CB1 antagonist AM251.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-2494965814

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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