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Study · In vitro (cells) · mouse · 2014

4 results

Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons.

Agosti F, López Soto EJ, Cabral A, Castrogiovanni D, Schioth HB, Perelló M, Raingo J

The European journal of neuroscience18 Jun 2014Cited by 16 (Europe PMC)

PMID24943127 (opens in a new tab)DOI10.1111/ejn.12650 (opens in a new tab)PepBankPUB-24943127
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In transfected HEK293 cells, melanotan II inhibited N-type calcium currents by 34.5 +/- 1.5%.

    In plain wordsIn cells, melanotan II reduced N-type calcium currents by about a third.

    Peptide
    Melanotan II
    Outcome
    DecreaseN-type calcium current inhibition in HEK293 cells
    Study

    n: not reported in source

    Transiently transfected HEK293 cells expressing N-type calcium channels
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    N-type calcium current inhibition
    34.5%
    HEK293 cells

    Source sentences

    Summary
    Using the patch-clamp technique, we found that the activation of MC4R with its agonist melanotan II specifically inhibited 34.5 ± 1.5% of N-type calcium currents in transiently transfected HEK293 cells.
  2. 02LabIn vitro (cells)Activity measurement

    In HEK293 cells, the inhibition of N-type calcium currents by melanotan II was concentration-dependent, voltage-independent and occluded by cholera toxin.

    In plain wordsIn cells, the effect of melanotan II on calcium currents grew with concentration and was blocked by a Gαs pathway inhibitor.

    Peptide
    Melanotan II
    Outcome
    DecreaseConcentration dependence and mechanism of N-type current inhibition
    Study

    n: not reported in source

    Transiently transfected HEK293 cells expressing N-type calcium channels
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This inhibition was concentration-dependent, voltage-independent and occluded by the Gαs pathway inhibitor cholera toxin.
  3. 03LabIn vitro (cells)Activity measurement

    In mouse cultured amygdala neurons, melanotan II inhibited native N-type calcium currents by 25.9 +/- 2.0%.

    In plain wordsIn mouse nerve cells in a dish, melanotan II reduced native N-type calcium currents by about a quarter.

    Peptide
    Melanotan II
    Outcome
    DecreaseNative N-type calcium current inhibition in amygdala neurons
    Study

    mousen: not reported in source

    Mouse cultured amygdala neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Native N-type calcium current inhibition
    25.9%
    mouse cultured amygdala neurons

    Source sentences

    Summary
    Moreover, we found that melanotan II specifically inhibited 25.9 ± 2.0% of native N-type calcium currents and 55.4 ± 14.4% of evoked inhibitory postsynaptic currents in mouse cultured amygdala neurons
  4. 04LabIn vitro (cells)Activity measurement

    In mouse cultured amygdala neurons, melanotan II inhibited evoked inhibitory postsynaptic currents by 55.4 +/- 14.4%.

    In plain wordsIn mouse nerve cells in a dish, melanotan II cut evoked inhibitory synaptic currents by about half.

    Peptide
    Melanotan II
    Outcome
    DecreaseEvoked inhibitory postsynaptic currents in amygdala neurons
    Study

    mousen: not reported in source

    Mouse cultured amygdala neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Evoked inhibitory postsynaptic current inhibition
    55.4%
    mouse cultured amygdala neurons

    Source sentences

    Summary
    Moreover, we found that melanotan II specifically inhibited 25.9 ± 2.0% of native N-type calcium currents and 55.4 ± 14.4% of evoked inhibitory postsynaptic currents in mouse cultured amygdala neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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