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Study · Animal study (in vivo) · rat · 2014

8 results

Protective effects of cerebrolysin in a rat model of optic nerve crush.

Huang TL, Huang SP, Chang CH, Lin KH, Sheu MM, Tsai RK

The Kaohsiung journal of medical sciences3 Apr 2014Cited by 4 (Europe PMC)

PMID24924838 (opens in a new tab)PMCIDPMC11916025 (opens in a new tab)DOI10.1016/j.kjms.2014.02.009 (opens in a new tab)PepBankPUB-24924838
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats with optic nerve crush, intra-ON cerebrolysin injection harmed the optic nerve.

    In plain wordsIn rats with optic nerve crush, cerebrolysin injection into the optic nerve caused harm.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableOptic nerve harm
    Study

    ratn = 20

    Optic nerve crush
    Outcome group
    Adverse events · Eye
    Studied dose
    Dose not stated · intra-ON injection · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment with intra-ON injection of Cbl was harmful to the optic nerve in the crush model.
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intravitreal cerebrolysin increased retinal ganglion cell density compared with PBS.

    In plain wordsIn rats with optic nerve crush, intravitreal cerebrolysin increased retinal ganglion cell density compared with PBS.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseRetinal ganglion cell density after intravitreal treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intravitreal injection · 2 weeksAs given in this study (rat).

    Measurements

    RGC density
    1125 /mm(2)
    Cbl-IVI
    RGC density
    641 /mm(2)
    PBS

    Source sentences

    Summary
    At 3 weeks postcrush, the densities of RGCs in the Cbl-IVI group (1125 ± 166/mm(2)) and in the Cbl-IPI treatment group (1328 ± 119/mm(2)) were significantly higher than those in the PBS group (641 ± 214/mm(2)).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intraperitoneal cerebrolysin increased retinal ganglion cell density compared with PBS.

    In plain wordsIn rats with optic nerve crush, intraperitoneal cerebrolysin increased retinal ganglion cell density compared with PBS.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseRetinal ganglion cell density after intraperitoneal treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intraperitoneal injection · 2 weeksAs given in this study (rat).

    Measurements

    RGC density
    1328 /mm(2)
    Cbl-IPI
    RGC density
    641 /mm(2)
    PBS

    Source sentences

    Summary
    At 3 weeks postcrush, the densities of RGCs in the Cbl-IVI group (1125 ± 166/mm(2)) and in the Cbl-IPI treatment group (1328 ± 119/mm(2)) were significantly higher than those in the PBS group (641 ± 214/mm(2)).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intravitreal cerebrolysin shortened P1 wave latency compared with PBS.

    In plain wordsIn rats with optic nerve crush, intravitreal cerebrolysin shortened visual response latency compared with PBS.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseP1 wave latency after intravitreal treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intravitreal injection · 2 weeksAs given in this study (rat).

    Measurements

    P1 latency
    105 ms
    Cbl-IVI
    P1 latency
    170 ms
    PBS

    Source sentences

    Summary
    The flash visual-evoked potential measurements showed that latency of the P1 wave was significantly shorter in the Cbl-IVI- and Cbl-IPI-treated groups (105 ± 4 ms and 118 ± 26 ms, respectively) than in the PBS-treated group (170 ± 20 ms).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intraperitoneal cerebrolysin shortened P1 wave latency compared with PBS.

    In plain wordsIn rats with optic nerve crush, intraperitoneal cerebrolysin shortened visual response latency compared with PBS.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseP1 wave latency after intraperitoneal treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intraperitoneal injection · 2 weeksAs given in this study (rat).

    Measurements

    P1 latency
    118 ms
    Cbl-IPI
    P1 latency
    170 ms
    PBS

    Source sentences

    Summary
    The flash visual-evoked potential measurements showed that latency of the P1 wave was significantly shorter in the Cbl-IVI- and Cbl-IPI-treated groups (105 ± 4 ms and 118 ± 26 ms, respectively) than in the PBS-treated group (170 ± 20 ms).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intraperitoneal cerebrolysin reduced ED1-positive cells at lesion sites compared with control eyes.

    In plain wordsIn rats with optic nerve crush, intraperitoneal cerebrolysin reduced ED1-positive cells compared with control eyes.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseED1-positive cells after intraperitoneal treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intraperitoneal injection · 2 weeksAs given in this study (rat).

    Measurements

    ED1-positive cells
    5 cells/high-power field
    Cbl IPI
    ED1-positive cells
    30 cells/high-power field
    Control eyes

    Source sentences

    Summary
    However, only Cbl IPI treatment resulted in a significant decrease in the number of ED1-positive cells at the lesion sites of the ON (5 ± 2 cells/vs. 30 ± 4 cells/high-power field in control eyes).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intravitreal cerebrolysin did not significantly reduce ED1-positive cells compared with control eyes.

    In plain wordsIn rats with optic nerve crush, intravitreal cerebrolysin did not significantly reduce ED1-positive cells compared with control eyes.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeED1-positive cells after intravitreal treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intravitreal injection · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, only Cbl IPI treatment resulted in a significant decrease in the number of ED1-positive cells at the lesion sites of the ON (5 ± 2 cells/vs. 30 ± 4 cells/high-power field in control eyes).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intra-ON cerebrolysin did not significantly reduce ED1-positive cells compared with control eyes.

    In plain wordsIn rats with optic nerve crush, intra-ON cerebrolysin did not significantly reduce ED1-positive cells compared with control eyes.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeED1-positive cells after intra-optic nerve treatment
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intra-ON injection · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, only Cbl IPI treatment resulted in a significant decrease in the number of ED1-positive cells at the lesion sites of the ON (5 ± 2 cells/vs. 30 ± 4 cells/high-power field in control eyes).
    2 context sentences
    Summary · context
    Rats received intravitreal injection of Cbl (n = 20), intra-ON injection of Cbl (n = 20), intraperitoneal injection (IPI) of Cbl (n = 20), or phosphate buffered saline (PBS; n = 20) every day for 2 weeks after ON crush injury.
    Summary · context
    At 3 weeks post-trauma, RGC density was counted by retrograde labeling with FluoroGold and visual function was assessed by flash visual-evoked potentials.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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