Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.

Kolik LG, Nadorova AV, Kozlovskaya MM

Bulletin of experimental biology and medicine1 May 2014Cited by 6 (Europe PMC)

PMID24913576DOI10.1007/s10517-014-2490-4PepBankPUB-24913576

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In alcohol-preferring rats, a single injection of Selank at 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in the elevated plus maze.
In plain wordsIn rats withdrawing from alcohol, one dose of Selank removed withdrawal-related anxiety in a maze test.
Peptide
Selank
Outcome
DecreaseWithdrawal-induced anxiety in elevated plus maze
Study
ratn: not reported in source
Alcohol-preferring outbred rats, 48-h alcohol withdrawal
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks.
Report a problemFND-2491357601
02AnimalAnimal study (in vivo)Efficacy outcome
In alcohol-preferring rats, a single injection of Selank at 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in the social interaction test.
In plain wordsIn rats withdrawing from alcohol, one dose of Selank removed withdrawal-related anxiety in a social test.
Peptide
Selank
Outcome
DecreaseWithdrawal-induced anxiety in social interaction test
Study
ratn: not reported in source
Alcohol-preferring outbred rats, 48-h alcohol withdrawal
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks.
Report a problemFND-2491357602
03AnimalAnimal study (in vivo)Efficacy outcome
In alcohol-preferring rats, a single injection of Selank at 0.3 mg/kg prevented the formation of mechanical allodynia during ethanol withdrawal.
In plain wordsIn rats withdrawing from alcohol, one dose of Selank prevented touch pain from forming.
Peptide
Selank
Outcome
DecreaseMechanical allodynia during withdrawal
Study
ratn: not reported in source
Alcohol-preferring outbred rats, 48-h alcohol withdrawal
Outcome group
Pain · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks.
Report a problemFND-2491357603
04AnimalAnimal study (in vivo)Efficacy outcome
In alcohol-preferring rats, a single injection of Selank at 0.3 mg/kg did not affect ethanol consumption.
In plain wordsIn rats that prefer alcohol, one dose of Selank did not change how much alcohol they drank.
Peptide
Selank
Outcome
No significant changeEthanol consumption
Study
ratn: not reported in source
Alcohol-preferring outbred rats, 48-h alcohol withdrawal
Outcome group
Appetite and food intake · Mental health and mood
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks.
Report a problemFND-2491357604

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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