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Study · In vitro (cells) · 2014

7 results

Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes.

Doroudian G, Pinney J, Ayala P, Los T, Desai TA, Russell B

Biomedical microdevices1 Oct 2014Cited by 15 (Europe PMC)

PMID24908137 (opens in a new tab)PMCIDPMC4418932 (opens in a new tab)DOI10.1007/s10544-014-9875-z (opens in a new tab)PepBankPUB-24908137
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human mesenchymal stem cells, MGF had no effect on cytoskeleton regulation, beyond the effect of microrods without MGF.

    In plain wordsIn human stem cells in a lab dish, MGF added no change to the cell skeleton beyond what the empty microrods did.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changehMSC cytoskeleton regulation by MGF
    Study

    humann: not reported in source

    human mesenchymal stem cells (hMSCs)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microrods without MGF regulated the cytoskeleton, adhesion, and proliferation of hMSCs, and MGF had no effect on these properties.
  2. 02LabIn vitro (cells)Activity measurement

    In human mesenchymal stem cells, MGF had no effect on adhesion, beyond the effect of microrods without MGF.

    In plain wordsIn human stem cells in a lab dish, MGF added no change to cell sticking beyond what the empty microrods did.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changehMSC adhesion with MGF
    Study

    humann: not reported in source

    human mesenchymal stem cells (hMSCs)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microrods without MGF regulated the cytoskeleton, adhesion, and proliferation of hMSCs, and MGF had no effect on these properties.
  3. 03LabIn vitro (cells)Activity measurement

    In human mesenchymal stem cells, MGF had no effect on proliferation, beyond the effect of microrods without MGF.

    In plain wordsIn human stem cells in a lab dish, MGF added no change to cell multiplying beyond what the empty microrods did.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changehMSC proliferation with MGF
    Study

    humann: not reported in source

    human mesenchymal stem cells (hMSCs)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microrods without MGF regulated the cytoskeleton, adhesion, and proliferation of hMSCs, and MGF had no effect on these properties.

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    Treatment with MGF-loaded microrods increased migration of human mesenchymal stem cells.

    In plain wordsIn human stem cells in a lab dish, microrods loaded with MGF made the cells move more.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreasehMSC migration with MGF microrod treatment
    Study

    humann: not reported in source

    human mesenchymal stem cells (hMSCs)
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Migration of human mesenchymal stem cells (hMSCs) increased with MGF microrod treatment (1.72 ± 0.23, p < 0.05).

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 05LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In neonatal rat ventricular myocytes under hypoxia, MGF microrod treatment protected against apoptosis, shown by the TUNEL assay.

    In plain wordsIn rat heart cells in a lab dish, MGF-loaded microrods protected the cells from dying under low oxygen.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseApoptosis in hypoxic myocytes (TUNEL)
    Study

    ratn: not reported in source

    neonatal rat ventricular myocytes under hypoxia
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Protection from apoptosis by MGF microrod treatment was shown by the TUNEL assay
    1 context sentence
    Summary · context
    Inhibition of the apoptotic pathway in neonatal rat ventricular myocytes was induced by 8 h of hypoxia (1 % O2).

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In neonatal rat ventricular myocytes under hypoxia, MGF microrod treatment increased Bcl-2 expression.

    In plain wordsIn rat heart cells in a lab dish, MGF-loaded microrods raised a protein that helps cells survive.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBcl-2 expression in hypoxic myocytes
    Study

    ratn: not reported in source

    neonatal rat ventricular myocytes under hypoxia
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    increased Bcl-2 expression (2 ± 0.19, p < 0.05).
    1 context sentence
    Summary · context
    Inhibition of the apoptotic pathway in neonatal rat ventricular myocytes was induced by 8 h of hypoxia (1 % O2).

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 07LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Pharmacokinetics

    Native MGF peptide was encapsulated within PEGDMA hydrogel microrods, with delivery for 2 weeks measured by HPLC.

    In plain wordsIn lab tests, microrods held the MGF peptide and released it for 2 weeks.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMGF encapsulation and delivery from microrods
    Study

    n: not reported in source

    PEGDMA hydrogel microrods
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Successful encapsulation of native MGF peptide within microrods was achieved with delivery of MGF for 2 weeks, as measured by HPLC.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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