In cultured bovine satellite cells, EGFR inhibition with AG1478 and EGFR silencing by siRNA each suppressed proliferation stimulated by LR3-IGF-1.
In plain wordsIn cattle muscle cells grown in the lab, blocking or silencing EGFR reduced the growth that LR3-IGF-1 stimulated.
- Peptide
- IGF-1 LR3
- Outcome
- DecreaseLR3-IGF-1-stimulated BSC proliferation after EGFR inhibition or silencing
- Study
cattlen: not reported in source
cultured bovine satellite cells- Outcome group
- Cell proliferation and differentiation · Musculoskeletal
Source sentences
Both AG1478 treatment and EGFR silencing also suppress proliferation stimulated by LR3-IGF-1 (an IGF1 analogue that binds normally to the insulin-like growth factor receptor (IGFR)-1 but has little or no affinity for IGF binding proteins) in cultured BSCs (P < 0.05).
1 context sentence(design, population, supporting numbers)
The objective of this study was to assess the role of the epidermal growth factor receptor (EGFR) in estradiol-17β (E2)-stimulated proliferation of cultured bovine satellite cells (BSCs).
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.