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Study · In vitro (cells) · mouse · 2014

4 results

NAP reduces murine microvascular endothelial cells proliferation induced by hyperglycemia.

D'Amico AG, Scuderi S, Maugeri G, Cavallaro S, Drago F, D'Agata V

Journal of molecular neuroscience : MN30 May 2014Cited by 25 (Europe PMC)

PMID24874579 (opens in a new tab)DOI10.1007/s12031-014-0335-2 (opens in a new tab)PepBankPUB-24874579
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In murine endothelial cells grown in high glucose, NAP significantly reduced cell viability.

    In plain wordsIn cells from mice grown in high glucose, NAP reduced cell viability.

    Peptide
    Davunetide
    Outcome
    DecreaseCell viability
    Study

    mousen: not reported in source

    murine microvascular endothelial cells in high glucose
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and cyclin D1 protein expression analysis revealed that NAP treatment significantly reduces viability and proliferation of the cells.
    1 context sentence
    Summary · context
    To this end we investigated the effects of NAP on an in vitro model of murine microvascular endothelial cells grown in high glucose for 7 days.
  2. 02LabIn vitro (cells)Activity measurement

    In murine endothelial cells grown in high glucose, NAP significantly reduced proliferation.

    In plain wordsIn cells from mice grown in high glucose, NAP reduced cell proliferation.

    Peptide
    Davunetide
    Outcome
    DecreaseCell proliferation
    Study

    mousen: not reported in source

    murine microvascular endothelial cells in high glucose
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and cyclin D1 protein expression analysis revealed that NAP treatment significantly reduces viability and proliferation of the cells.
    1 context sentence
    Summary · context
    To this end we investigated the effects of NAP on an in vitro model of murine microvascular endothelial cells grown in high glucose for 7 days.
  3. 03LabIn vitro (cells)Mechanism

    In murine endothelial cells grown in high glucose, NAP reduced ERK phosphorylation.

    In plain wordsIn cells from mice grown in high glucose, NAP reduced ERK phosphorylation.

    Peptide
    Davunetide
    Outcome
    DecreaseERK phosphorylation
    Study

    mousen: not reported in source

    murine microvascular endothelial cells in high glucose
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP treatment reduced the phosphorylation levels of ERK and AKT in cells grown in high glucose.
    1 context sentence
    Summary · context
    To this end we investigated the effects of NAP on an in vitro model of murine microvascular endothelial cells grown in high glucose for 7 days.
  4. 04LabIn vitro (cells)Mechanism

    In murine endothelial cells grown in high glucose, NAP reduced AKT phosphorylation.

    In plain wordsIn cells from mice grown in high glucose, NAP reduced AKT phosphorylation.

    Peptide
    Davunetide
    Outcome
    DecreaseAKT phosphorylation
    Study

    mousen: not reported in source

    murine microvascular endothelial cells in high glucose
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP treatment reduced the phosphorylation levels of ERK and AKT in cells grown in high glucose.
    1 context sentence
    Summary · context
    To this end we investigated the effects of NAP on an in vitro model of murine microvascular endothelial cells grown in high glucose for 7 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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