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Study · Randomized controlled trial · 2014

2 results

Early life stress modulates amygdala-prefrontal functional connectivity: implications for oxytocin effects.

Fan Y, Herrera-Melendez AL, Pestke K, Feeser M, Aust S, Otte C, Pruessner JC, Böker H, Bajbouj M, Grimm S

Human brain mapping26 May 2014Cited by 101 (Europe PMC)

PMID24862297 (opens in a new tab)PMCIDPMC6869775 (opens in a new tab)DOI10.1002/hbm.22553 (opens in a new tab)PepBankPUB-24862297
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy young men with lower early life stress scores, oxytocin attenuated the link between pgACC-amygdala resting connectivity and pgACC deactivation during psychosocial stress.

    In plain wordsIn healthy young men with lower early life stress scores, oxytocin weakened the link between resting brain connectivity and stress response, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseRest-task interaction of pgACC-amygdala connectivity in subjects with lower ELS
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In subjects with lower ELS scores, stronger pgACC-amygdala rs-FC predicted stronger pgACC deactivation during the psychosocial stress task, and this rest-task interaction was attenuated by OXT.
    1 context sentence
    Summary · context
    Eighteen healthy young males participated in a resting-state fMRI study of OXT effects using a double-blind, randomized, placebo-controlled, within-subject crossover design.
  2. 02HumanRandomized controlled trialMechanism

    In healthy young men with higher early life stress scores, oxytocin had no significant effect on the rest-task interaction of pgACC-amygdala connectivity.

    In plain wordsIn healthy young men with higher early life stress scores, oxytocin had no significant effect on the link between resting brain connectivity and stress response.

    Peptide
    Oxytocin
    Outcome
    No significant changeRest-task interaction of pgACC-amygdala connectivity in subjects with higher ELS
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In subjects with higher ELS scores however, the rest-task interaction was altered and OXT showed no significant effect.
    1 context sentence
    Summary · context
    Eighteen healthy young males participated in a resting-state fMRI study of OXT effects using a double-blind, randomized, placebo-controlled, within-subject crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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