Skip to content

Study · Animal study (in vivo) · rhesus macaque · 2014

8 results

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques.

Modi ME, Connor-Stroud F, Landgraf R, Young LJ, Parr LA

Psychoneuroendocrinology3 Mar 2014Cited by 108 (Europe PMC)

PMID24845176 (opens in a new tab)PMCIDPMC4120060 (opens in a new tab)DOI10.1016/j.psyneuen.2014.02.011 (opens in a new tab)PepBankPUB-24845176
Source linkPubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus macaques, intranasal oxytocin significantly increased plasma oxytocin concentrations.

    In plain wordsIn rhesus macaques, oxytocin given by nose spray raised oxytocin levels in the blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after intranasal administration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rhesus macaque).

    Source sentences

    Summary
    All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus macaques, intravenous oxytocin significantly increased plasma oxytocin concentrations.

    In plain wordsIn rhesus macaques, oxytocin given into a vein raised oxytocin levels in the blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after intravenous administration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus macaque).

    Source sentences

    Summary
    All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus macaques, aerosolized oxytocin significantly increased plasma oxytocin concentrations.

    In plain wordsIn rhesus macaques, aerosolized oxytocin raised oxytocin levels in the blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after aerosolized administration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · aerosolizedAs given in this study (rhesus macaque).

    Source sentences

    Summary
    All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus macaques, aerosolized oxytocin was the only route that significantly increased cerebrospinal fluid oxytocin concentrations.

    In plain wordsIn rhesus macaques, only aerosolized oxytocin raised oxytocin levels in the fluid around the brain and spine.

    Peptide
    Oxytocin
    Outcome
    IncreaseCSF oxytocin after aerosolized administration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · aerosolizedAs given in this study (rhesus macaque).

    Source sentences

    Summary
    All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT.
    3 context sentences
    Summary · context
    This study confirms that the AE route is the most effective method for increasing central OT concentrations in monkeys, and may also be an effective route, alternative to IN, for administering OT to some human populations.
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus macaques, intranasal oxytocin did not significantly increase cerebrospinal fluid oxytocin concentrations.

    In plain wordsIn rhesus macaques, oxytocin given by nose spray did not raise oxytocin levels in the fluid around the brain and spine.

    Peptide
    Oxytocin
    Outcome
    No significant changeCSF oxytocin after intranasal administration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rhesus macaque).

    Source sentences

    Summary
    All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus macaques, intravenous oxytocin did not significantly increase cerebrospinal fluid oxytocin concentrations.

    In plain wordsIn rhesus macaques, oxytocin given into a vein did not raise oxytocin levels in the fluid around the brain and spine.

    Peptide
    Oxytocin
    Outcome
    No significant changeCSF oxytocin after intravenous administration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus macaque).

    Source sentences

    Summary
    All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rhesus macaques, none of the three oxytocin routes changed plasma vasopressin concentrations.

    In plain wordsIn rhesus macaques, none of the three oxytocin routes changed vasopressin levels in the blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma vasopressin concentration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intranasal, intravenous and aerosolizedAs given in this study (rhesus macaque).

    Source sentences

    Summary
    No route affected concentrations of AVP in plasma or CSF.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rhesus macaques, none of the three oxytocin routes changed cerebrospinal fluid vasopressin concentrations.

    In plain wordsIn rhesus macaques, none of the three oxytocin routes changed vasopressin levels in the fluid around the brain and spine.

    Peptide
    Oxytocin
    Outcome
    No significant changeCSF vasopressin concentration
    Study

    rhesus macaquen: not reported in source

    Rhesus macaques
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intranasal, intravenous and aerosolizedAs given in this study (rhesus macaque).

    Source sentences

    Summary
    No route affected concentrations of AVP in plasma or CSF.
    2 context sentences
    Summary · context
    First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF.
    Summary · context
    Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.