The medial preoptic nucleus as a site of the thermogenic and metabolic actions of melanotan II in male rats.

Monge-Roffarello B, Labbe SM, Lenglos C, Caron A, Lanfray D, Samson P, Richard D

American journal of physiology. Regulatory, integrative and comparative physiology1 Jul 2014Cited by 24 (Europe PMC)

PMID24808495DOI10.1152/ajpregu.00059.2014PepBankPUB-24808495

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In male rats, MTII infusion in the medial preoptic nucleus increased interscapular brown adipose tissue temperature.
In plain wordsIn male rats, MTII infused into a brain area raised the temperature of brown fat.
Peptide
Melanotan II
Outcome
IncreaseiBAT temperature
Study
ratn: not reported in source
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
Infusion of MTII in the MPO led to increases in interscapular brown adipose tissue (iBAT) temperature and iBAT uptake of 14C-bromopalmitate.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849501
02AnimalAnimal study (in vivo)Mechanism
In male rats, MTII infusion in the medial preoptic nucleus increased brown adipose tissue uptake of 14C-bromopalmitate.
In plain wordsIn male rats, MTII infused into a brain area increased fat uptake into brown fat.
Peptide
Melanotan II
Outcome
IncreaseiBAT uptake of 14C-bromopalmitate
Study
ratn: not reported in source
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
Infusion of MTII in the MPO led to increases in interscapular brown adipose tissue (iBAT) temperature and iBAT uptake of 14C-bromopalmitate.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849502
03AnimalAnimal study (in vivo)Mechanism
In rats with dorsomedial hypothalamic lesions, the MTII-induced increase in iBAT temperature was blocked.
In plain wordsIn rats with damage to a certain brain area, MTII no longer raised brown fat temperature.
Peptide
Melanotan II
Outcome
No significant changeiBAT temperature increase in rats with DMH lesions
Study
ratn: not reported in source
rats with DMH lesions (kainic acid)
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
Both increases were blocked by DMH lesions
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849503
04AnimalAnimal study (in vivo)Mechanism
In rats with dorsomedial hypothalamic lesions, the MTII-induced increase in iBAT 14C-bromopalmitate uptake was blocked.
In plain wordsIn rats with damage to a certain brain area, MTII no longer increased fat uptake into brown fat.
Peptide
Melanotan II
Outcome
No significant changeiBAT 14C-bromopalmitate uptake in rats with DMH lesions
Study
ratn: not reported in source
rats with DMH lesions (kainic acid)
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
Both increases were blocked by DMH lesions
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849504
05AnimalAnimal study (in vivo)Other
In rats, the iBAT temperature increase (area under curve) and 14C-bromopalmitate uptake were correlated.
In plain wordsIn rats, the rise in brown fat temperature went together with higher fat uptake into brown fat.
Peptide
Melanotan II
Outcome
Not applicableCorrelation of iBAT temperature increase with 14C-bromopalmitate uptake
Study
ratn: not reported in source
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Measurements
Correlation coefficient r
0.63 r
iBAT temperature AUC vs 14C-bromopalmitate uptake
Source sentences
Summary
iBAT temperature increase (area under curve) and 14C-bromopalmitate uptake emerged as two correlated variables (r = 0.63, P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849505
06AnimalAnimal study (in vivo)Mechanism
In rats, MTII infusion in the MPO induced iBAT mRNA expression of thermogenesis genes Dio2 and Pgc1a; DMH lesions blocked this.
In plain wordsIn rats, MTII infused into a brain area switched on heat-production genes in brown fat; brain-area damage blocked this.
Peptide
Melanotan II
Outcome
IncreaseiBAT thermogenesis gene mRNA expression (Dio2, Pgc1a)
Study
ratn: not reported in source
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
DMH lesions also blocked MTII-induced expression of mRNAs coding for proteins involved in 1) thermogenesis [type II iodothyronine deiodinase (Dio2) and peroxisome proliferator-activated receptor gamma coactivator 1-α (Pgc1α)]
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849506
07AnimalAnimal study (in vivo)Mechanism
In rats, MTII infusion in the MPO induced iBAT mRNA expression of the lipolysis gene Hsl; DMH lesions blocked this.
In plain wordsIn rats, MTII infused into a brain area switched on a fat-breakdown gene in brown fat; brain-area damage blocked this.
Peptide
Melanotan II
Outcome
IncreaseiBAT lipolysis gene mRNA expression (Hsl)
Study
ratn: not reported in source
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
DMH lesions also blocked MTII-induced expression of mRNAs coding for proteins involved in
Summary
2) lipolysis [hormone-sensitive lipase (Hsl)]
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849507
08AnimalAnimal study (in vivo)Mechanism
In rats, MTII infusion in the MPO induced iBAT mRNA expression of lipogenesis genes Dgat2 and Fas; DMH lesions blocked this.
In plain wordsIn rats, MTII infused into a brain area switched on fat-making genes in brown fat; brain-area damage blocked this.
Peptide
Melanotan II
Outcome
IncreaseiBAT lipogenesis gene mRNA expression (Dgat2, Fas)
Study
ratn: not reported in source
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
DMH lesions also blocked MTII-induced expression of mRNAs coding for proteins involved in
Summary
3) lipogenesis [diacylglycerol-O-acyltransferase 2 (Dgat2), fatty acid synthase (Fas)], in iBAT of rats killed 1 h after MPO infusion of MTII.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849508
09AnimalAnimal study (in vivo)Mechanism
In rats, MTII stimulated expression of genes in inguinal white adipose tissue (Glut4, Gpat3, Dgat1, Dgat2, Atgl, Hsl, Cpt1b) only in rats with DMH lesions.
In plain wordsIn rats, MTII switched on fat-handling genes in white fat only when a certain brain area was damaged.
Peptide
Melanotan II
Outcome
IncreaseiWAT gene expression in rats with DMH lesions
Study
ratn: not reported in source
rats with DMH lesions (kainic acid)
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · infusion into the medial preoptic nucleus (MPO)As given in this study (rat).
Source sentences
Summary
MTII also stimulated expression of genes in iWAT but only in rats with DMH lesions.
2 context sentences(design, population, supporting numbers)
Summary · context
These genes included glucose transporter member 4 (Glut4), glycerol-3-phosphate acyltransferase 3 (Gpat3), Dgat1, Dgat2, triglyceride lipase (Atgl), Hsl, and carnitine palmitoyltransferase 1β (Cpt1β).
Summary · context
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII).
Report a problemFND-2480849509

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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