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Study · Not a test of the peptide alone · 2014

1 result

Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells.

Guan FY, Gu J, Li W, Zhang M, Ji Y, Li J, Chen L, Hatch GM

Life sciences5 May 2014Cited by 35 (Europe PMC)

PMID24802125 (opens in a new tab)DOI10.1016/j.lfs.2014.04.034 (opens in a new tab)PepBankPUB-24802125
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In palmitate-injured MIN6 cells, AICAR attenuated compound K-mediated inhibition of apoptosis.

    In plain wordsIn cells, AICAR reduced compound K's protection against palmitate-induced cell death.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCK-mediated inhibition of apoptosis
    Study

    mousen: not reported in source

    palmitate-injured MIN6 β-cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The AMPK activator AICAR attenuated the CK-mediated inhibition of palmitate-induced apoptosis.
    1 context sentence
    Summary · context
    Treatment effect of CK on type 2 diabetic (T2D) mice and palmitate-induced MIN6 β-cells injury was observed.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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