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Study · Randomized controlled trial · 2014

3 results

A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia.

Gibson CM, Penn DL, Smedley KL, Leserman J, Elliott T, Pedersen CA

Schizophrenia research3 May 2014Cited by 75 (Europe PMC)

PMID24799299 (opens in a new tab)DOI10.1016/j.schres.2014.04.009 (opens in a new tab)PepBankPUB-24799299
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with schizophrenia, fear recognition improved within the oxytocin group over six weeks.

    In plain wordsIn adults with schizophrenia, fear recognition improved within the group that took oxytocin. The abstract gives no comparison with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFear recognition
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · 6 weeksAs given in this study (human).

    Source sentences

    Summary
    Results showed within group improvements in fear recognition, perspective taking
    1 context sentence
    Summary · context
    Fourteen participants with schizophrenia were randomized to receive either intranasal oxytocin or a placebo solution and completed a battery of social cognitive, social skills and clinical psychiatric symptom measures.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with schizophrenia, perspective taking improved within the oxytocin group over six weeks.

    In plain wordsIn adults with schizophrenia, perspective taking improved within the group that took oxytocin. The abstract gives no comparison with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePerspective taking
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · 6 weeksAs given in this study (human).

    Source sentences

    Summary
    Results showed within group improvements in fear recognition, perspective taking
    1 context sentence
    Summary · context
    Fourteen participants with schizophrenia were randomized to receive either intranasal oxytocin or a placebo solution and completed a battery of social cognitive, social skills and clinical psychiatric symptom measures.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with schizophrenia, negative symptoms were reduced within the oxytocin group over six weeks.

    In plain wordsIn adults with schizophrenia, negative symptoms fell within the group that took oxytocin. The abstract gives no comparison with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseNegative symptoms
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 6 weeksAs given in this study (human).

    Source sentences

    Summary
    a reduction in negative symptoms in the oxytocin group.
    1 context sentence
    Summary · context
    Fourteen participants with schizophrenia were randomized to receive either intranasal oxytocin or a placebo solution and completed a battery of social cognitive, social skills and clinical psychiatric symptom measures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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