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Study · Not a test of the peptide alone · 2014

3 results

Study of interactions between DNA and tetrapeptides using methods of molecular mechanics.

Tarnovskaya SI, Yakutseni PP, Khavinson VKh

Bulletin of experimental biology and medicine25 Mar 2014Cited by 1 (Europe PMC)

PMID24770759 (opens in a new tab)DOI10.1007/s10517-014-2426-z (opens in a new tab)PepBankPUB-24770759
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Pancragen (KEDW) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Pancragen (KEDW).

  1. 01Computer modelNot a test of Pancragen (KEDW) aloneIn silicoMechanism

    In molecular models, Lys-Glu-Asp-Trp could interact with both minor and major grooves of DNA.

    In plain wordsComputer models predicted that Lys-Glu-Asp-Trp could interact with both DNA grooves.

    Peptide
    Pancragen (KEDW)
    Outcome
    Not applicableDNA groove interaction
    Study

    n: not reported in source

    molecular mechanics models of tetrapeptide-DNA interactions
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Molecular modeling shows that this tetrapeptide can interact with not only minor, but also major groove of DNA molecule.

    In this study, Pancragen (KEDW) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pancragen (KEDW).

  2. 02Computer modelNot a test of Pancragen (KEDW) aloneIn silicoMechanism

    In molecular models, the tetrapeptide's major-groove interaction was more specific and depended on peptide and DNA sequences.

    In plain wordsComputer models predicted more specific interaction with the major DNA groove, dependent on peptide and DNA sequences.

    Peptide
    Pancragen (KEDW)
    Outcome
    Not applicableMajor-groove interaction specificity
    Study

    n: not reported in source

    molecular mechanics models of tetrapeptide-DNA interactions
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The interaction with the major groove is more specific, because it depends on the primary sequences of the tetrapeptide and DNA.

    In this study, Pancragen (KEDW) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pancragen (KEDW).

  3. 03Computer modelNot a test of Pancragen (KEDW) aloneIn silicoMechanism

    In molecular models, GGCAG was the putative DNA binding site for the tetrapeptide.

    In plain wordsComputer models identified GGCAG as a possible DNA binding site for the tetrapeptide.

    Peptide
    Pancragen (KEDW)
    Outcome
    Not applicablePutative DNA binding sequence
    Study

    n: not reported in source

    molecular mechanics models of tetrapeptide-DNA interactions
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Sequence GGCAG is the putative binding site for the tetrapeptide.

    In this study, Pancragen (KEDW) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pancragen (KEDW).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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