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Study · In vitro (cells) · 2014

8 results

Microencapsulation of mechano growth factor E peptide for sustained delivery and bioactivity maintenance.

Niu X, Chen P, Jia X, Wang L, Li P, Yang L, Wang Y, Fan Y

International journal of pharmaceutics23 Apr 2014Cited by 12 (Europe PMC)

PMID24768406 (opens in a new tab)DOI10.1016/j.ijpharm.2014.04.054 (opens in a new tab)PepBankPUB-24768406
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In in vitro bioactivity assays, MGF-Ct24E accelerated the proliferation of MC3T3-E1 cells.

    In plain wordsIn cells in a lab dish, an MGF peptide made bone-type cells multiply faster.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMC3T3-E1 cell proliferation
    Study

    n: not reported in source

    MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro bioactivity assays reveal that the MGF-Ct24E can accelerate MC3T3-E1 cells proliferation and delay their differentiation as well.
  2. 02LabIn vitro (cells)Activity measurement

    In in vitro bioactivity assays, MGF-Ct24E delayed the differentiation of MC3T3-E1 cells.

    In plain wordsIn cells in a lab dish, an MGF peptide slowed the maturing of bone-type cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMC3T3-E1 cell differentiation
    Study

    n: not reported in source

    MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro bioactivity assays reveal that the MGF-Ct24E can accelerate MC3T3-E1 cells proliferation and delay their differentiation as well.

Studies that did not test the peptide alone6

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 03LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    MGF-Ct24E loaded in chitosan/tripolyphosphate microspheres showed long-term effects.

    In plain wordsIn cells in a lab dish, the MGF peptide loaded in microspheres kept showing effects over a long time.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableLong-term effects of encapsulated MGF-Ct24E
    Study

    n: not reported in source

    MC3T3-E1 cells on CS/TPP microspheres
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The encapsulated MGF-Ct24E shows long-term effects after being loaded in the CS/TPP microspheres

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Other

    Cells showed excellent morphology on the surface of the MGF-Ct24E-loaded microspheres.

    In plain wordsIn cells in a lab dish, the cells looked healthy on the surface of the peptide-loaded microspheres.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableCell morphology on microspheres
    Study

    n: not reported in source

    MC3T3-E1 cells on CS/TPP microspheres
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    the cells exhibit excellent morphology on the surface of microspheres.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 05LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Pharmacokinetics

    From chitosan/tripolyphosphate microspheres, the release of encapsulated MGF-Ct24E reached 84.6% after 2 weeks of in vitro degradation.

    In plain wordsIn lab tests, microspheres released 84.6% of their MGF peptide load after 2 weeks.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMGF-Ct24E release from microspheres
    Study

    n: not reported in source

    chitosan/tripolyphosphate microspheres
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Release amount
    84.6%
    CS/TPP/MGF-Ct24E, 2 weeks

    Source sentences

    Summary
    the release amount of MGF-Ct24E reaches 84.6% after degrading for 2 weeks
    1 context sentence
    Summary · context
    The chitosan/tripolyphosphate microspheres encapsulated with MGF-Ct24E (CS/TPP/MGF-Ct24E)

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 06LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other

    The total weight loss of the MGF-Ct24E-loaded chitosan/tripolyphosphate microspheres was 32% after TPP disappeared.

    In plain wordsIn lab tests, the peptide-loaded microspheres lost 32% of their weight as they broke down.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMicrosphere total weight loss
    Study

    n: not reported in source

    chitosan/tripolyphosphate microspheres
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Total weight loss
    32%
    CS/TPP/MGF-Ct24E

    Source sentences

    Summary
    With the disappearance of TPP, the total weight loss of CS/TPP/MGF-Ct24E is 32%

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  5. 07LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Pharmacokinetics

    During in vitro hydrolytic degradation, the TPP component disintegrated first and the microspheres maintained sustained delivery of MGF-Ct24E.

    In plain wordsIn lab tests, the microspheres kept releasing the MGF peptide steadily as they broke down.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableSustained delivery during in vitro degradation
    Study

    n: not reported in source

    chitosan/tripolyphosphate microspheres
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The TPP component disintegrates in advance of CS matrix and the MGF-Ct24E maintains sustained delivery during in vitro hydrolytic degradation.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  6. 08LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other

    The MGF-Ct24E-loaded microspheres were micron-sized and spherical with a smooth surface.

    In plain wordsIn lab tests, the peptide-loaded microspheres were tiny, round and smooth.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMicrosphere size and shape
    Study

    n: not reported in source

    chitosan/tripolyphosphate microspheres
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The microspheres are micron-sized and spherical in shape with smooth surface morphology.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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