Skip to content

Study · Systematic review · 2014

4 results

Neurofunctional maps of the 'maternal brain' and the effects of oxytocin: a multimodal voxel-based meta-analysis.

Rocchetti M, Radua J, Paloyelis Y, Xenaki LA, Frascarelli M, Caverzasi E, Politi P, Fusar-Poli P

Psychiatry and clinical neurosciences9 Jun 2014Cited by 56 (Europe PMC)

PMID24734987 (opens in a new tab)DOI10.1111/pcn.12185 (opens in a new tab)PepBankPUB-24734987
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanSystematic reviewMechanism

    In a voxel-based meta-analysis of fMRI studies, oxytocin administration increased left insular activation during emotional tasks versus placebo.

    In plain wordsIn brain-imaging studies pooled together, oxytocin raised activity in the left insula compared with placebo during emotional tasks.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft insula activation with oxytocin
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    greater left insular activation associated with oxytocin administration versus placebo.
    1 context sentence
    Summary · context
    We performed two systematic literature searches: fMRI studies investigating the neurofunctional correlates of the 'maternal brain' by employing mother-infant paradigms; and fMRI studies employing oxytocin during emotional tasks.
  2. 02HumanSystematic reviewMechanism

    In the pooled fMRI studies, oxytocin was linked to deactivation of the dorsomedial frontal cortex, whereas mothers showed activation there.

    In plain wordsIn brain-imaging studies pooled together, oxytocin lowered activity in one frontal brain area where mothers showed higher activity.

    Peptide
    Oxytocin
    Outcome
    DecreaseDorsomedial frontal cortex activity with oxytocin
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    dorsomedial frontal cortex activation in mothers but deactivation with oxytocin.
    1 context sentence
    Summary · context
    We performed two systematic literature searches: fMRI studies investigating the neurofunctional correlates of the 'maternal brain' by employing mother-infant paradigms; and fMRI studies employing oxytocin during emotional tasks.
  3. 03HumanSystematic reviewMechanism

    Left insula, basal ganglia, frontotemporal gyri, bilateral thalamus and amygdala showed consistent activation across the mother-infant and oxytocin paradigms.

    In plain wordsIn pooled brain-imaging studies, several brain areas were active both in mothers with infants and after oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseOverlap of oxytocin-related and maternal-brain activation (left insula, basal ganglia, thalamus, amygdala)
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Left insula extending to basal ganglia and frontotemporal gyri as well as bilateral thalamus and amygdala showed consistent activation across the two paradigms.
    1 context sentence
    Summary · context
    We performed two systematic literature searches: fMRI studies investigating the neurofunctional correlates of the 'maternal brain' by employing mother-infant paradigms; and fMRI studies employing oxytocin during emotional tasks.
  4. 04HumanSystematic reviewMechanism

    The right insula was activated across the mother-infant and oxytocin paradigms in the pooled fMRI studies.

    In plain wordsIn pooled brain-imaging studies, the right insula was active both in mothers with infants and after oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseRight insula activation across paradigms
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Right insula also showed activation across the two paradigms
    1 context sentence
    Summary · context
    We performed two systematic literature searches: fMRI studies investigating the neurofunctional correlates of the 'maternal brain' by employing mother-infant paradigms; and fMRI studies employing oxytocin during emotional tasks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.