Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair.

Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N

Bone13 Apr 2014Cited by 17 (Europe PMC)

PMID24731926DOI10.1016/j.bone.2014.04.005PepBankPUB-24731926

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with femoral osteotomy, PTH1-34 amplified the injury-induced increase in Gla-OC.
In plain wordsIn rats with femoral osteotomy, PTH1-34 amplified the increase in carboxylated osteocalcin after injury.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCarboxylated osteocalcin
Study
ratn: not reported in source
Femoral osteotomy
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
PTH1-34 amplified the osteotomy-induced increase in Gla-OC and improved the mechanical properties as well as the volumetric bone mineral tissue density of the fracture callus.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether vitamin K influences the efficacy of PTH1-34 therapy for bone repair in a rat osteotomy model.
Summary · context
Skeletal repair was assessed by micro-computed tomography, mechanical testing, and histology at 8weeks after surgery.
Report a problemFND-2473192601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with femoral osteotomy, PTH1-34 improved callus mechanical properties.
In plain wordsIn rats with femoral osteotomy, PTH1-34 improved the mechanical properties of healing bone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus mechanical properties
Study
ratn: not reported in source
Femoral osteotomy
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
PTH1-34 amplified the osteotomy-induced increase in Gla-OC and improved the mechanical properties as well as the volumetric bone mineral tissue density of the fracture callus.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether vitamin K influences the efficacy of PTH1-34 therapy for bone repair in a rat osteotomy model.
Summary · context
Skeletal repair was assessed by micro-computed tomography, mechanical testing, and histology at 8weeks after surgery.
Report a problemFND-2473192602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with femoral osteotomy, PTH1-34 improved volumetric bone mineral tissue density of the callus.
In plain wordsIn rats with femoral osteotomy, PTH1-34 increased mineral tissue density in healing bone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus volumetric bone mineral tissue density
Study
ratn: not reported in source
Femoral osteotomy
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
PTH1-34 amplified the osteotomy-induced increase in Gla-OC and improved the mechanical properties as well as the volumetric bone mineral tissue density of the fracture callus.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether vitamin K influences the efficacy of PTH1-34 therapy for bone repair in a rat osteotomy model.
Summary · context
Skeletal repair was assessed by micro-computed tomography, mechanical testing, and histology at 8weeks after surgery.
Report a problemFND-2473192603

Studies that did not test the peptide alone2

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

04AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with femoral osteotomy, concurrent warfarin reduced mechanical recovery during PTH1-34 therapy.
In plain wordsIn rats with femoral osteotomy, adding warfarin reduced mechanical recovery compared with PTH1-34 therapy alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseMechanical recovery with warfarin
Study
ratn: not reported in source
Femoral osteotomy
Comparator
PTH1-34 monotherapy
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Concurrent use of warfarin decreased the response to PTH1-34 therapy in terms of mechanical recovery, probably by impairing mineralization due to the lack of Gla-OC.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether vitamin K influences the efficacy of PTH1-34 therapy for bone repair in a rat osteotomy model.
Summary · context
Skeletal repair was assessed by micro-computed tomography, mechanical testing, and histology at 8weeks after surgery.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2473192604
05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with sufficient dietary vitamin K, PTH1-34 plus vitamin K2 did not significantly improve bone repair over PTH1-34 alone.
In plain wordsIn rats with sufficient vitamin K, adding vitamin K2 did not significantly improve bone repair over PTH1-34 alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeBone repair with vitamin K2
Study
ratn: not reported in source
Femoral osteotomy
Comparator
PTH1-34 monotherapy
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Although the effects of combination therapy with PTH1-34 and vitamin K2 on bone repair did not significantly exceed those of PTH1-34 monotherapy in rats fed sufficient dietary vitamin K
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether vitamin K influences the efficacy of PTH1-34 therapy for bone repair in a rat osteotomy model.
Summary · context
Skeletal repair was assessed by micro-computed tomography, mechanical testing, and histology at 8weeks after surgery.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2473192605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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