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Study · Animal study (in vivo) · sheep · 2014

2 results

The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*.

Maybauer MO, Maybauer DM, Enkhbaatar P, Laporte R, Wiśniewska H, Traber LD, Lin C, Fan J, Hawkins HK, Cox RA, Wiśniewski K, Schteingart CD, Landry DW, Rivière PJ, Traber DL

Critical care medicine1 Jul 2014Cited by 59 (Europe PMC)

PMID24674922 (opens in a new tab)PMCIDPMC4346299 (opens in a new tab)DOI10.1097/ccm.0000000000000300 (opens in a new tab)PepBankPUB-24674922
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep, selepressin almost completely blocked fluid accumulation, whereas arginine vasopressin partially reduced it.

    In plain wordsIn sheep with sepsis, selepressin blocked fluid accumulation more than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseFluid accumulation
    Study

    sheepn: not reported in source

    Pseudomonas aeruginosa pneumonia-induced severe sepsis
    Comparator
    Arginine vasopressin
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated · continuous intravenous infusionAs given in this study (sheep).

    Source sentences

    Summary
    this fluid accumulation was partially reduced by arginine vasopressin and almost completely blocked by selepressin
    3 context sentences
    Summary · context
    Prospective, randomized, controlled laboratory experiment.
    Summary · context
    Forty-five chronically instrumented sheep.
    Summary · context
    Sheep were anesthetized, insufflated with cooled cotton smoke via tracheostomy, and P. aeruginosa were instilled into their airways.

Studies that did not test the peptide alone1

In this study, Selepressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Selepressin.

  1. 02AnimalNot a test of Selepressin aloneAnimal study (in vivo)Efficacy outcome

    In septic sheep, combined selepressin and desmopressin increased fluid accumulation to levels similar to arginine vasopressin treatment.

    In plain wordsIn sheep with sepsis, selepressin with desmopressin produced fluid accumulation levels similar to arginine vasopressin treatment.

    Peptide
    Selepressin
    Outcome
    Direction not reportedFluid accumulation with desmopressin
    Study

    sheepn: not reported in source

    Pseudomonas aeruginosa pneumonia-induced severe sepsis
    Comparator
    Arginine vasopressin treatment
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    and combined infusion of selepressin and desmopressin increased fluid accumulation to levels similar to arginine vasopressin treatment.
    3 context sentences
    Summary · context
    Prospective, randomized, controlled laboratory experiment.
    Summary · context
    Forty-five chronically instrumented sheep.
    Summary · context
    Sheep were anesthetized, insufflated with cooled cotton smoke via tracheostomy, and P. aeruginosa were instilled into their airways.

    In this study, Selepressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Selepressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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