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Study · Animal study (in vivo) · rabbit · 2014

8 results

PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis.

Orth P, Cucchiarini M, Wagenpfeil S, Menger MD, Madry H

Osteoarthritis and cartilage21 Mar 2014Cited by 36 (Europe PMC)

PMID24662735 (opens in a new tab)DOI10.1016/j.joca.2014.03.010 (opens in a new tab)PepBankPUB-24662735
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult rabbits, PTH [1-34] increased subarticular spongiosa volume versus saline.

    In plain wordsIn rabbits, PTH [1-34] increased bone volume beneath joint cartilage compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubarticular spongiosa volume
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH [1-34] enhanced volume, mineral density, and trabecular thickness within the subarticular spongiosa, and increased thickness of the calcified cartilage layer (all P < 0.05).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult rabbits, PTH [1-34] increased subarticular spongiosa mineral density versus saline.

    In plain wordsIn rabbits, PTH [1-34] increased bone mineral density beneath joint cartilage compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubarticular spongiosa mineral density
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH [1-34] enhanced volume, mineral density, and trabecular thickness within the subarticular spongiosa, and increased thickness of the calcified cartilage layer (all P < 0.05).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult rabbits, PTH [1-34] increased subarticular spongiosa trabecular thickness versus saline.

    In plain wordsIn rabbits, PTH [1-34] increased trabecular thickness beneath joint cartilage compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubarticular trabecular thickness
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH [1-34] enhanced volume, mineral density, and trabecular thickness within the subarticular spongiosa, and increased thickness of the calcified cartilage layer (all P < 0.05).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult rabbits, PTH [1-34] increased calcified cartilage layer thickness versus saline.

    In plain wordsIn rabbits, PTH [1-34] increased calcified cartilage thickness compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCalcified cartilage thickness
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH [1-34] enhanced volume, mineral density, and trabecular thickness within the subarticular spongiosa, and increased thickness of the calcified cartilage layer (all P < 0.05).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In adult rabbits, PTH [1-34] produced cartilage surface irregularities versus saline.

    In plain wordsIn rabbits, PTH [1-34] produced irregular cartilage surfaces compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCartilage surface irregularities
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    Moreover, PTH [1-34] led to cartilage surface irregularities and reduced matrix staining (both P < 0.03).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In adult rabbits, PTH [1-34] reduced cartilage matrix staining versus saline.

    In plain wordsIn rabbits, PTH [1-34] reduced cartilage matrix staining compared with saline.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseCartilage matrix staining
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg daily · subcutaneous · 6 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    Moreover, PTH [1-34] led to cartilage surface irregularities and reduced matrix staining (both P < 0.03).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.

Studies that did not test the peptide alone2

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

  1. 07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism

    In PTH [1-34]-treated rabbits, early osteoarthritic changes correlated with increased calcified cartilage thickness.

    In plain wordsIn rabbits given PTH [1-34], early joint damage was linked to thicker calcified cartilage.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableCartilage degeneration association with calcified cartilage thickness
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    These early osteoarthritic changes correlated with and were ascribed to the increased thickness of the calcified cartilage layer (P = 0.026) and enhanced mineral density of the subarticular spongiosa (P = 0.001).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

  2. 08AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism

    In PTH [1-34]-treated rabbits, early osteoarthritic changes correlated with increased subarticular spongiosa mineral density.

    In plain wordsIn rabbits given PTH [1-34], early joint damage was linked to denser bone beneath the cartilage.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableCartilage degeneration association with subarticular mineral density
    Study

    rabbitn: not reported in source

    Adult rabbits with naïve osteochondral units
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    These early osteoarthritic changes correlated with and were ascribed to the increased thickness of the calcified cartilage layer (P = 0.026) and enhanced mineral density of the subarticular spongiosa (P = 0.001).
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 10 μg PTH [1-34]/kg were given to adult rabbits for 6 weeks, controls received saline.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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